Alaabta

Ornithine aspartate wuxuu ahaa kii ugu horreeyay ee kiliinikada loo isticmaalo daawaynta hungover iyo hepatic encephalopathy.Iyada oo ururinta waayo-aragnimada codsiga kiliinikada, ornithine aspartate ayaa si ballaaran loo isticmaalay daaweynta cudurrada beerka, waxayna ku guulaysteen saameyno daaweyneed oo sax ah oo ku saabsan hepatic encephalopathy, dhaawaca beerka ee daroogada, beerka dufanka leh, cagaarshow dabadheeraad ah iyo cudurrada kale, ayaa si ballaaran loo isticmaalay. aqoonsaday dhakhaatiirta.

Ornithine aspartate wuxuu bixiyaa substrate HOL iyo glutamine synthesis in vivo.Glutamine waa sheyga sun-saarista ammonia, iyo sidoo kale qaabka kaydinta iyo gaadiidka ee ammonia.Marka la eego xaaladaha jireed iyo jireed, isku-darka urea iyo isku-darka glutamine-ka waxaa saameeya ornithine, aspartic acid iyo xeryahooda kale ee dicarboxyl.Ornithine waxay ku lug leedahay ku dhawaad ​​dhammaan habka firfircoonida wareegga urea iyo sun-saarista ammonia.Arginine ayaa la sameeyaa inta lagu jiro habkan, ka dibna urea waa la kala saaraa si ay u sameyso ornithine.Aspartic acid wuxuu ka qaybqaataa isku-darka nucleic acid ee hepatocytes si loo fududeeyo hagaajinta hepatocytes ee dhaawacan.Intaa waxaa dheer, iyada oo ay ugu wacan tahay kor u qaadista aan tooska ahayn ee aspartic acid ee habka dheef-shiid kiimikaadka ee wareegga tricarboxylic acid ee unugyada beerka, waxay kor u qaadaa tamarta tamarta unugyada beerka, taas oo u sahlaysa hagaajinta unugyada beerka ee dhaawacan waxayna dardargelisaa soo kabashada shaqada beerka.Horumarkii ugu dambeeyay ayaa muujiyay in aspartate ay sidoo kale joojin karto dhaqdhaqaaqa bararka iyada oo loo marayo N-methyl-D-aspartate (NMDA) receptors, taas oo yareyneysa habka farmasiga ee jawaab-celinta beerka.NMDA reseptors waa nooc-hoosaadka ionotropic excitatory glutamate reseptors, kuwaas oo door muhiim ah ka ciyaara hababka jireed sida gudbinta synaptik, balaastikada synaptik, barashada iyo xusuusta habka dhexe ee neerfayaasha.Daraasadaha cilmi-nafsiga ee xiga ayaa sidoo kale xaqiijiyay in aspartate ay si weyn u wanaajisay nabarrada bararka ee beerka.

Codsiga bukaan socodka

Dhanka cudurada beerka: Ornithine aspartate waxaa si weyn loogu isticmaalaa dawada ka hortagga caabuqa iyo hepatoprotective daawaynta cudurada beerka ee kala duwan, sida hepatic encephalopathy, dhaawaca beerka ee daroogada, beerka dufan, cagaarshow chronic, iwm. dhiiga ammonia ee bukaanka qaba xanuunka maskaxda iyo nafisinta calaamadaha neuropsychiatric ayaa si tartiib tartiib ah u noqonaya daawada ugu weyn ee daaweynta cudurrada beerka ee kala duwan.

Ornithine aspartate waa substrate lagama maarmaan u ah isku dhafka urea iyo glutamine.Ornithine wuxuu kicin karaa enzymes-yada muhiimka ah ee habka isku-dhafka urea - ornithine carbamoyltransferase iyo carbamoyl phosphate synthase, iyo kor u qaadida dheef-shiid kiimikaadka ammonia si loo gaaro detoxification dhiiga ammonia, aspartic acid sida substrate waxay dhalin kartaa glutamic acid iyo oxaloacetic acid, glutamine waa sheyga sun-saarista. ammonia, iyo sidoo kale waa kaydinta iyo gaadiidka ammonia.Oxaloacetate waxay ka qaybqaadataa wareegga tricarboxylic acid, waxay kor u qaadaa wax soo saarka tamarta unugyada beerka, waxayna u suurtagelisaa unugyada beerka dhaawacan in la dayactiro, dib loo soo celiyo, iyo dib u soo celinta shaqada beerka.Ornithine aspartate waxay si wax ku ool ah u wanaajin kartaa shaqada beerka, waxay yaraynaysaa ammonia dhiigga, waxayna si isku mid ah u yaraynaysaa ammonia oo leh lactulose iyo ofloxacin, taas oo si weyn u wanaajinaysa heerka daawaynta ee encephalopathy hepatic, taas oo u qalanta codsi caafimaad.

Oncology: Isbeddellada joogtada ah ee noocyada iyo qiyaasta daawooyinka kemotherabi, dhibaatooyinka la xiriira daawooyinka kiimoterabiga ayaa sidoo kale soo baxaya, dhaawaca beerka ayaa ah mid ka mid ah dhaawaca xubnaha caadiga ah.Marka dhaawaca beerku dhaco, waxay saamaynaysaa caafimaadka jidhka iyo maskaxda ee bukaanada heerar kala duwan, waxay caqabad ku noqon doontaa hirgelinta hababka daaweynta kemotherabi, waxayna daciifin doontaa saamaynta daaweynta kemotherabi.Xaalado daran, beerka oo gaboobay ayaa laga yaabaa inay nafta halis geliso.Ornithine aspartate waxay si weyn u wanaajin kartaa dhaawaca beerka ee ay keento daawooyinka kemotherabi waxayna wanaajisaa saameynta daaweynta bukaanka burooyinka.

Goobta qalliinka: Qalliinka qalliinku wuxuu dharbaaxo ku yahay dhammaan xubnaha jirka ee bukaanka, dhaawaca shaqada beerka ee qalliinka kadib waa dhibaato caadi ah.Ornithine aspartate waxay ka hortagi kartaa oo daweyn kartaa dhaawaca beerka qalliinka ka dib waxayna kor u qaadeysaa soo kabashada bukaanada.