Alaabta

Dhowr analoog guanosine ah, ie acyclovir (iyo dawada afka laga qaato valaciclovir), penciclovir (oo ku jira qaabka dawada afka laga qaato, famciclovir) iyo ganciclovir, ayaa si weyn loogu isticmaalaa daawaynta fayraska herpes. 2 (HSV-2), fayraska varicella-zoster (VZV) iyo/ama cytomegalovirus aadanaha (HCMV)] caabuqyada.Sanadihii la soo dhaafay, dhowr analogues guanosine cusub ayaa la sameeyay, oo ay ku jiraan 3-xubnood ee cyclopropylmethyl iyo -methenyl derivatives (A-5021 iyo synguanol) iyo 6-xubnaha D- iyo L-cyclohexenyl derivatives.Dhaqdhaqaaqa analoogyada acyclic/carbocyclic guanosine ayaa lagu go'aamiyay ka soo horjeeda noocyo badan oo fayras ah, oo ay ku jiraan HSV-1, HSV-2, VZV, HCMV, iyo sidoo kale fayraska herpes bini'aadamka nooca 6 (HHV-6), nooca 7 (HHV- 7) iyo nooca 8 (HHV-8), iyo fayraska cagaarshow B (HBV).Analooga cusub ee guanosine (ie A-5021 iyo D- iyo L-cyclohexenyl G) ayaa la ogaaday inay si gaar ah ugu firfircoon yihiin fayrasyadaas (HSV-1, HSV-2, VZV) kuwaas oo u codeeya thymidine kinase gaar ah (TK), oo soo jeedinaya. in hawlahooda ka hortagga fayraska (ugu yaraan qayb ahaan) ay ku xiran tahay fosforyaalka uu keeno fayrasku TK.Dhaqdhaqaaqa ka hortagga fayraska ee calaamadeysan ayaa sidoo kale lagu xusay A-5021 oo ka dhan ah HHV-6 iyo D- iyo L-cyclohexenyl G oo ka dhan ah HCMV iyo HBV.Dhaqdhaqaaqa ka-hortagga fayraska ee analogues acyclic/carbocyclic nucleoside waxaa si cad u xoojin kara mycophenolic acid, oo awood u leh xakameynta inosine 5'-monophosphate (IMP) dehydrogenase.Analoogga cusub ee carbocyclic guanosine (ie A-5021 iyo D- iyo L-cyclohexenyl G) waxay hayaan ballanqaad weyn, ma aha oo kaliya wakiilada fayraska ee daaweynta caabuqyada fayraska, laakiin sidoo kale wakiilada antitumor ee isku-darka daaweynta hidde-wadaha / kemotherabi kansarka. waase haddii (qayb ka mid ah) unugyada burooyinka ay beddeleen fayraska (HSV-1, VZV) TK.