Alaabta

Hepatotoxicity ee musharaxiinta daroogada waa mid ka mid ah welwelka ugu weyn ee baarista daroogada ee helitaanka hore ee daroogada.Ogaanshaha cadaadiska oksaydhative ee hepatic waxay noqon kartaa tilmaame hore ee hepatotoxicity iyo faa'iidooyinka xulashada daroogada.Labada lamaane ee glutathione (GSH) iyo glutathione disulfide (GSSG), oo ah mid ka mid ah dib-u-habaynta intracellular redox ee lamaanayaasha, ayaa door muhiim ah ka ciyaara ilaalinta unugyada cadaadiska oksaydhka ee ay keento isku dheelitir la'aanta u dhaxaysa prooxidants iyo antioxidants.Go'aaminta tirada GSSG/GSH iyo uruurinta GSH iyo GSSG ayaa loo isticmaalay in lagu muujiyo diiqada oksaydhka ee unugyada iyo unugyada.Daraasaddan, waxaan ku tijaabinay suurtagalnimada isticmaalka saamiga GSSG/GSH ee biliary sida biomarker si ay u muujiso cadaadiska oksaydhiyaha cagaarshowga iyo sunta daroogada.Afar xeryood oo loo yaqaan inay beddelaan heerarka GSH iyo GSSG ayaa lagu tijaabiyay daraasaddan.Diquat (diquat dibromide monohydrate) iyo acetaminophen ayaa la siiyay jiirka.Paraquat iyo tert-butyl hydroperoxide ayaa la maamulay d jiirarka si loo keeno isbeddelada biliary GSH iyo GSSG.biliary GSH iyo GSSG waxaa lagu qiyaasey iyadoo la isticmaalayo qaloocyada cabbirka ee lagu diyaariyey bile macmal ah si loogu xisaabtamo saameynta matrix kasta oo xameeti ah ee falanqaynta LC-MS iyo si looga fogaado faragelinta GSH iyo GSSG.Iyada oo leh afar tusaale (jiirka iyo jiirarka) ee isbeddelada daroogada ay keentay ee kinetics ee saamiga biliary GSSG/GSH, daraasaddan ayaa muujisay suurtogalnimada horumarinta tusaha jawaab-celinta soo-gaadhista ee ku salaysan saamiga GSSG / GSH ee biliary ee saadaalinta cadaadiska oksaydhka ee hepatic.