Gentamycin Sulfate CAS: 1405-41-0 budada cad
| Lambarka buugaagta | XD90364 |
| Magaca Alaabta | Gentamycin sulfate |
| CAS | 1405-41-0 |
| Qaanuunka molecular | C21H43N5O7H2So4 |
| Miisaanka Molecular | 575.68 |
| Faahfaahinta Kaydinta | 2 ilaa 8 °C |
| Xeerka Tarifka La Iswaafajiyay | 29419000 |
Tilmaamaha Alaabta
| Biyo | 15% ugu badnaan |
| pH | 3.5-5.5 |
| Qiimayn | 590IU/mg daq |
| Wareegid gaar ah | +107° ilaa +121° |
| Muuqashada | budo cad |
| Sulfate (SO4) | 32 - 35% |
| Dambaska sulfated | <1.0% |
Dhaawaca laf-dhabarka ee aan fiicneyn ayaa ku adkaata luminta oligodendrocytes, taasoo keentay demyelination joogto ah.Sidaa darteed, xeeladaha ku-tallaalidda si ay u bixiyaan unugyada lineage oligodendrocyte iyo si kor loogu qaado baaxadda myelination u muuqataa in ay sabab u tahay dayactirka laf dhabarta.Daraasadda hadda jirta waxay baaris ku samaysay in ku-tallaalidda unugyada unugyada neerfaha ee bini'aadamka (NSCs) ee hidde ahaan loo beddelay si loo muujiyo qodobka Olig2, oo ah nidaamiye lagama maarmaanka u ah horumarinta oligodendrocyte, wuxuu hagaajin karaa soo kabashada lugaha iyo kor u qaadida myelination ee qaabka dhaawaca laf dhabarta ee jiirka.HB1.F3 (F3) ) xariiqda NSC ee bini'aadamka ee aan dhimanin waxaa lagu beddelay vector retroviral oo codeynaya Olig2, oo ah maareeyaha muhiimka ah ee horumarinta oligodendrocyte.Xad-dhaafka ah ee Olig2 ee NSC-yada bini'aadamka (F3.Olig2) waxay kicisay firfircoonida NKX2.2 iyo kala-soocidda tooska ah ee NSCs ee unugyada lineage oligodendrocyte ee vitro.Horudhaca Olig2 waxa ay keentay firfircooni fidineed oo sare, iyo tiro aad u badan oo F3.Olig2 NSCs ah ayaa la ogaaday 7 toddobaad kadib markii lagu beeray xudunta laf-dhabarka ee aan la daboolin marka loo eego kan waalidka F3 NSCs.F3.Olig2 NSCs waxay soo bandhigeen haajiraan soo noqnoqda oo ku wajahan arrinta cad, halka F3 NSCs ay inta badan ku koobnaayeen walxaha cawl ama agagaarka godadka nabarrada.Inta badan F3.Olig2 NSC-yada ku jira maadada cad-cad ee la badbaadiyay oo loo kala saaray oligodendrocytes baaluq.Ku-tallaalidda F3.Olig2 NSCs waxay kordhisay mugga walxaha cad ee la badbaadiyay waxayna hoos u dhigtay mugga daloolka.Waxaa intaa dheer, tallaalada F3.Olig2 waxay si weyn u kordhiyeen dhumucda galka myelin ee ku wareegsan axons ee walxaha cad ee badbaadsan.Ugu dambeyntii, xayawaanka leh F3.Olig2 grafts waxay muujiyeen hagaajinta tayada goobaha hindlimbs. Gudbinta NSC-yada hidde ahaan loo beddelay si loo kala saaro lineage oligodendrocytic waxay noqon kartaa istaraatijiyad wax ku ool ah si loo hagaajiyo natiijooyinka shaqeynta ka dib dhaawaca laf dhabarta.Daraasadda hadda jirta waxay soo jeedinaysaa in arrimaha molecular-ka ee xukuma go'aamada masiirka unugga la maareyn karo si loo helo awoodda dib-u-celinta ee daaweynta unugyada.
