Furazolidone Cas: 67-45-8
Lambarka buugaagta | XD91885 |
Magaca Alaabta | Furazolidone |
CAS | 67-45-8 |
Qaabka molecularla | C8H7N3O5 |
Miisaanka Molecular | 225.16 |
Faahfaahinta Kaydinta | Ambient |
Xeerka Tarifka La Iswaafajiyay | 29349990 |
Tilmaamaha Alaabta
Muuqashada | Budada jaalaha ah |
Asay | 99% min |
barta dhalaalaysa | 254-256°C (dac.) |
Barta karkarinta | 366.66°C (qiyaasta qallafsan) |
cufnaanta | 1.5406 (qiyaasta adag) |
index refractive | 1.7180 (qiyaas) |
Fp | 2 °C |
milmayn | formic acid: milma 50mg/mL |
pka | -1.98±0.20 (La saadaaliyay) |
Xasaasi ah | Iftiinka xasaasiga ah |
ugu badnaan | 365nm(DMSO)( shid) |
Xasilooni | DegganGubi karaAan ku habboonayn walxaha oksaydhaynta ee xooggan. |
Bakteeriyada bakteeriyada furazolidone waxay la mid tahay tan furazolidone.Daawada ka hortagga caabuqa, waxay wax ku ool u tahay daaweynta Salmonella, Shigella, Escherichia coli, Proteus, Streptococcus, iyo Staphylococcus aureus.Bakteeriyadu ma fududa inay yeeshaan iska caabbinta daawada dawadan.Sidoo kale ma laha wax iska caabin ah oo leh antibiyootiga fasalka sulfa.Waxaa inta badan loo isticmaalaa daaweynta bukaan-jiifka, enteritis, tiifowga, paratyphoid iyo daaweynta jirka la mariyo ee trichomoniasis siilka.
2. Badeecadu waa fungicides kaas oo leh spectrum bakteeriyada ballaaran.Daawada ka hortagga caabuqa, waxay waxtar u leedahay daawaynta noocyo kala duwan oo bakteeriyada Gram-positive ah iyo kuwa taban oo ay ku jiraan Escherichia coli, Bacillus anthracis, iyo Paratyphoid bacilli.Ma aha oo kaliya wax ku ool ah daaweynta dysentery, enteritis, laakiin sidoo kale loo isticmaalo daaweynta caabuqyada siilka.Sannadihii ugu dambeeyay, waxay waxtar wanaagsan u leedahay daaweynta qandhada tiifowga.Sida daroogo loogu talagalay daawooyinka xayawaanka iyo cabitaanka, waxay leedahay saameyn liddi ku ah bakteeriyada Salmonella, Escherichia coli iyo Salmonella pullorum sidoo kale waxay leedahay saameyn ka hortag ah oo ku saabsan protozoa (bakteeriyada coccidia, iwm.) waxayna u nugul yihiin inay abuuraan caabbinta daroogada.Qadar yar oo furazolidone ah ayaa loo isticmaalay codsiyada kale (sida rinjiga biyaha ku milma iyo saxarka waraaqaha) sida fungicides.
3. Waa daawo ka hortagta caabuqa oo loo isticmaalo caabuqa mindhicirka.
4. Furazolidone, sida fungicides, waxay leedahay spectrum bakteeriyada ballaaran.Bakteeriyada ugu nugul waa Escherichia coli, Bacillus anthracis, usha paratyphoid, Shigella, iyo Klebsiella oof-wareen.Salmonella typhi sidoo kale waa u nugul yahay.Waxaa inta badan loo isticmaalaa daawaynta nuucyada u nugul ee uu keeno dysentery, enteritis, iyo daacuun.Waxa kale oo loo isticmaali karaa daawaynta tiifowga, paratyphoid, giardiasis, iyo trichomoniasis.Isku darka dawooyinka ka-hortagga aashitada ayaa loo isticmaali karaa daawaynta caabuqa caloosha ee ay keento Helicobacter pylori.Guryaha: budada jaalaha ah ama budada crystalline, aan ur lahayn, marka hore aan dhadhamin ka dibna waxoogaa qadhaadh noqda;aad u yar oo ku milma biyaha iyo ethanol;wax yar ku milmay chloroform oo aan lagu milmi karin ether, ku milma dimethylformamide iyo nitromethane.Mp: 255 ilaa 259 °C.Burburka inta uu milmay.
Furazolidone waxaa loo isticmaalaa infekshannada caloosha iyo mindhicirka.Inta badan waxaa loo isticmaalaa wadamada soo koraya si loogu daweeyo cudurada shubanka ee etiology kala duwan, laakiin ma aha dawada la doortay haddii pathogene gaar ah la aqoonsaday.U isticmaal sida wakiilka safka labaad ee giardiasis iyo qayb ka mid ah dawooyinka dawooyinka badan ee caabuqa Helicobacter ayaa la soo jeediyay.
3-[(5-Nitrofurylidene)amino]-2-oxazolidinone (Furoxone) waxay u dhacdaa sida budada crystalline jaalaha ah oo leh dhadhan qadhaadh. Waa mid aan ku milmin biyaha ama khamriga.Furazolidone waxa ay leedahay bakteeriyaal ka dhan ah noocyo badan oo cudur-sidaha mindhicirka ah, oo ay ku jiraan S. aureus, E. coli, Salmonella, Shigella, Proteus spp., Enterobacter, iyo Vibrio cholerae. Waxa kale oo ay ka hortagtaa protozoan Giardia lamblia.Waxaa lagu talinayaa in lagu daweeyo afka bakteeriyada ama protozoaldrhea ee ay sababaan noolaha nugul.Qiyaasta caadiga ah ee dadka waaweyn waa 100 mg 4 jeer maalintii.
Kaliya qayb yar oo ka mid ah qiyaasta afka laga maamulo ee furazolidoneis ayaa la nuugay.Qiyaastii 5% qiyaasta afka ayaa lagu ogaan karaa kaadida oo ah qaab dhowr dheef-shiid kiimikaad ah.Qaar ka mid ah cidhiidhiga caloosha iyo mindhicirka ayaa lagu soo warramey isticmaalkeeda. Khamriga waa in la iska ilaaliyaa marka furazolidone la isticmaalo sababtoo ah daawadu waxay joojin kartaa aldehyde dehydrogenase.