Kaska Folic Acid: 59-30-3 99%
| Lambarka buugaagta | XD90435 |
| Magaca Alaabta | Folic acid |
| CAS | 59-30-3 |
| Qaanuunka molecular | C19H19N7O6 |
| Miisaanka Molecular | 441.40 |
| Faahfaahinta Kaydinta | Ambient |
| Xeerka Tarifka La Iswaafajiyay | 29362900 |
Tilmaamaha Alaabta
| Muuqashada | Budada crystalline jaalaha ama oranji |
| Qiimayn | 99% |
| Biyo | 5.0 - 8.5% |
| Daahirnimada Chromatographic | <2.0% |
| Solubility | Dhab ahaantii aan ku milmin biyaha iyo inta badan dareerayaasha organic.Waxay ku milantaa asiidh-ku-darka iyo xalalka alkaline |
| Hadhaaga dabka | <0.3% |
Daraasaddan, thermosensitive iyo folate functionalized poly(ethylene oxide) -b-poly(propylene oxide) -b-poly(ethylene oxide) -ploy(N-isopropylacrylamide-co-hydroxyethyl methacrylate) (FA-Pluronic-PNH) kopolymer ahaa farsamaysan.Qaab dhismeedka iyo miisaanka kelli ee koobiyeerka waxaa xaqiijiyay 1H NMR, FT-IR iyo GPC, siday u kala horreeyaan.Heerkulka ugu hooseeya ee xalinta halista ah (LCST) ee kopolymer-ku wuxuu ahaa 39.8 darajo C. Iyadoo la adeegsanaayo doxorubicin (DOX) daawo moodello ah, folate reseptor- targeted DOX-load micelles ayaa lagu sii sameeyay kobolymer-ka.Miceles-ka bannaan iyo DOX- raran labaduba waxay soo bandhigeen qaabab wareegsan oo isku celcelis ahaan dhexroorkoodu wuxuu ahaa 35 nm iyo 50 nm, siday u kala horreeyaan.Dabeecadaha siidaynta in vitro ee DOX-ku raran yihiin waxay ahaayeen kuwo heerkulku ku xidhan yahay heerka sii daynta DOX ee 42 darajo C (ka sarraysa LCST) wuu ka dheereeyay kan 37 darajo C (hoos LCST).Intaa waxaa dheer, tijaabooyinka cytotoxicity ee DOX iyo DOX-ku raran yihiin oo ku saabsan khadadka unugyada kansarka ilmo-galeenka ee bini'aadamka HeLa iyo khadadka unugyada kansarka sanbabada bini'aadamka A549 waxay muujiyeen in folate ay kordhisay qaadashada gacanta ee miceles gudaha unugyada la beegsaday kuwaas oo si weyn u caddeeyey soo-dhoweeyayaasha folate.
