Alaabta

Flucytosine, oo sidoo kale loo yaqaan 5-fluorocytosine ama 5-FC, waa daawada fangas-ka-hortagga ee synthetic oo marka hore loo isticmaalo daaweynta caabuqyada fangas.Waxaa loo kala saaraa sida antimetabolite, taas oo macnaheedu yahay in ay farageliso hababka dheef-shiid kiimikaadka caadiga ah ee unugyada fangas, taasoo horseedaysa xannibaaddooda ama dhimashadooda.Flucytosine waxaa badanaa lagu maamulaa iyadoo lagu darayo wakiilada kale ee antifungal ee waxtarka ugu fiican. Mid ka mid ah isticmaalka muhiimka ah ee flucytosine waa daaweynta caabuqyada fangas-ka-soo-baxa, gaar ahaan kuwa ay keenaan noocyada Candida iyo Cryptococcus.Inta badan waxaa lagu daraa wakiilka kale ee fungal, sida amphotericin B ama fluconazole, si kor loogu qaado hawlaheeda antifungal.Flucytosine waxay u shaqeysaa iyada oo gelaysa unugyada fangas waxayna maraysaa beddelaad 5-fluorouracil, antimetabolite cytotoxic ah.5-fluorouracil ka dib waxay faragelisaa isku-darka fangas RNA iyo DNA, taas oo ka hortagaysa korriinka fungal iyo soo-celinta.Habkan isku-dhafka ah wuxuu kaa caawinayaa in lala dagaallamo nooc ballaadhan oo fangas ah oo keena waxtarka daaweynta. Isticmaalka kale ee muhiimka ah ee flucytosine wuxuu ku jiraa daaweynta Cryptococcus neoformans meningitis, caabuq nafta halis gelin kara oo saameeya xuubabka ku wareegsan maskaxda iyo xudunta lafdhabarta.Flucytosine waxaa loo tixgeliyaa mid ka mid ah daawaynta safka hore ee lagu daro amphotericin B ee daaweynta xaaladdan.Daawaynta isku dhafan waxay caawisaa inay ka gudubto xaddidaadda daroogo kasta oo kali ah oo ay gaadho heerar sare oo daaweyn ah.Flucytosine waxay gaartaa heerar ku filan dareeraha cerebrospinal, taas oo u oggolaanaysa inay si wax ku ool ah u beegsato caabuqa fangas ee habka dhexe ee dareenka.Si kastaba ha noqotee, isticmaalkeeda waxaa laga yaabaa inay xaddidan tahay khatarta ah inay soo baxdo iska caabbinta, maadaama fungusku uu heli karo isbeddello ka dhigaya mid u nugul daroogada.Korjoogteynta dhow iyo qiimeynta xilliyeed ee jawaab-celinta daweynta ayaa muhiim ah marka la isticmaalayo flucytosine si loo hubiyo natiijooyinka daaweynta habboon.In kasta oo flucytosine guud ahaan si wanaagsan loo dulqaadan karo, waxay yeelan kartaa saameyn xun.Dhibaatooyinka caadiga ah waxaa ka mid ah khalkhalka caloosha iyo mindhicirka, sida lallabbo, matag, iyo shuban.Waxa kale oo ay sababi kartaa xakamaynta dhuuxa lafta, taas oo keeni karta hoos u dhaca wax soo saarka unugyada dhiigga.Tijaabooyin dhiig oo joogto ah ayaa inta badan la sameeyaa si loola socdo tirada unugyada dhiigga inta lagu jiro daawaynta. Soo koobid, flucytosine waa dawo antifungal ah oo loo isticmaalo daaweynta isku dhafan ee daaweynta caabuqyada fangas, gaar ahaan kuwa ay keenaan noocyada Candida iyo Cryptococcus.Waxay u shaqeysaa iyada oo faragalinaysa isku-dhafka aashitada nucleic ee fangas, xannibaysa korriintooda iyo soo-celintooda.Flucytosine waxaa caadi ahaan loo isticmaalaa in lagu daro wakiilada kale ee antifungal waxayna si gaar ah muhiim ugu tahay daaweynta Cryptococcus neoformans meningitis.Si kastaba ha ahaatee, isticmaalkeedu wuxuu u baahan yahay la socosho taxadar leh sababtoo ah khatarta iska caabbinta iyo saameynta xun ee iman karta.