Alaabta

Saamaynta aashitada, oo ah astaanta biochemical ee buro microenvironment, ee horumarka kansarka iyo metastasis waa mid adag.Saamaynta pro- iyo ka-hortagga-tumorigenic ee acidosis labadaba waa la soo sheegay iyo microenvironment-ka aashitada ayaa looga faa'iidaystay gaarsiinta gaarka ah ee daawooyinka, walxaha sawir-qaadista, iyo dhismooyinka hidaha ee burooyinka.Daraasaddan waxaan ku baaraynaa fidinta iyo ku dhegganaanta xudunta u ah unugyada melanoma ee B16F10 kuwaas oo hidde ahaan loo farsameeyay si ay xad-dhaaf u muujiyaan pH-dareemada G borotiinka-ku-xidhan yahay receptor GPR4.Anaga oo adeegsanayna qiimaynta ku-xidhka unugga waxa aanu ogaanay in GPR4-ka xad-dhaafka ah uu daahiyay faafidda unugga oo ay bedeshay meelaynta meelaynta isku-xidhka firfircoon ee firfircoon, sida meelaynta focal adhesion kinase (FAK) iyo paxillin, pH acidic.Waxaa sidoo kale la baaray dariiqyada calaamadaha G-protein-ka iyo kuwa hoose ee ka mas'uulka ah saameyntan.Iyada oo la adeegsanayo Rho inhibitor CT04 (C3 transferase), Rho-Associate kinase (ROCK) inhibitors Y27632 iyo thiazovivin, myosin light chain kinase (MLCK) inhibitor staurosporine ama G12/13 inhibitory ah, faafinta unugyada ayaa dib loo soo celiyay halka xannibaadda iyo Dhaqdhaqaaqa waddooyinka Gq iyo Gs wax yar ama saameyn ma yeelan.Isku soo wada duuboo natiijooyinkayagu waxay muujinayaan in iyada oo loo marayo dariiqa calaamadaynta G12/13/Rho ee GPR4 ay wax ka beddesho dhaqdhaqaaqyada adhesion-ka ee xoogga leh waxayna yaraynaysaa faafidda unugyada iyo xuubka xuubka.