Alaabta

Waxtarka molecules antibiyootiga ee daawaynta Pseudomonas aeruginosa oof-wareenka ayaa hoos u dhacaysa natiijada faafinta iska caabbinta bakteeriyada.Jiritaanka hababka isgaarsiineed ee bakteeriyada, sida dareenka kooramka, ayaa bixiyay fursado cusub oo daaweyn ah.Lactonases si wax ku ool ah u demiyaan koorum bakteeriyada ku salaysan acyl-homoserine lactone, oo ku lug leh enzymes kuwaas oo ah daawooyinka anti-Pseudomonas cusub oo laga yaabo in lagu qiimeeyo oof-wareen. Ujeedada daraasaddan hadda waxay ahayd in la qiimeeyo awoodda laktonase ee loo yaqaan SsoPox-I si loo yareeyo dhimashada jiirka P. aeruginosa pneumonia.Si loo qiimeeyo SsoPox-I-dhexdhexaadinta koorum quenching, waxaan marka hore cabbirnay dhaqdhaqaaqa fayrasyada hidda-socodka lasB, synthesis of pyocianin, dhaqdhaqaaqa proteolytic ee joojinta bakteeriyada iyo samaynta biofilm ee a. Nooca PAO1 oo ku koray joogitaanka lactonase.Qaabka halista ah ee dilaaga ah ee P. aeruginosa pneumonia ee jiirka, waxaanu qiimeynay saameynta hore ama dib u dhigista daaweynta tracheal ee SsoPox-I ee dhimashada, bakteeriyada sambabada iyo dhaawaca sambabada. , Pyocianin synthesis, dhaqdhaqaaqa proteolytic iyo samaynta biofilm.Isticmaalka hore ee SsoPox-I ayaa hoos u dhigtay dhimashada jiirka ee qaba oof-wareen ba'an 75% ilaa 20%.Dhaawaca sambabada ee taariikhiga ah ayaa si weyn hoos ugu dhacay laakiin tirada bakteeriyada sanbabada laguma beddelin daawaynta.Daawaynta daahitaanka ayaa lala xiriiriyay hoos u dhac aan micno lahayn oo dhimasho ah.Natiijooyinkani waxay muujinayaan saamaynta ilaalinta lactonase SsoPox-I ee P. aeruginosa pneumonia waxayna u furaan dariiqa isticmaalka daaweynta mustaqbalka.