Alaabta

Cardioprotectant: Creatine phosphate waa walax tamar bixisa oo muhiim u ah foosha murqaha iyo dheef-shiid kiimikaadka.Waa kaydka tamarta kiimikaad ee muruqa siman iyo muruqa qallafsan, waxaana loo isticmaalaa dib-u-soo-celinta ATP.Phosphocreatinedisodium waa qaabkeeda daawada.Sodium Creatine Phosphate, magaca kiimikaad N-[imino(phosphono)methyl]-N-methylglycine disodium cusbo, waa walax ka hortag wadnaha ah oo uu bilaabay Talyaani Ouhui Pharmaceutical Factory ee 1992. Foomka phosphocreatine wuxuu ciyaaraa doorar nafsiyeed oo kala duwan oo muhiim ah, waxaana si ballaaran loo isticmaalaa. loogu talagalay ilaalinta myokardiyaha ee bukaannada qaba ischemia wadnaha ama inta lagu jiro qalliinka wadnaha ee Kiimikada, iyo daaweynta cudurrada wadnaha iyo xididdada sida wadnaha oo aan shaqeynin, wadnaxanuun myocardial iyo arrhythmia.Waxay wanaajin kartaa shaqada wadnaha iyo kala duwanaanshaha garaaca wadnaha ee bukaanada qaba ischaemic cardiomyopathy.Kaliya ma siin karto tamar unugyada myocardial marka ay ka cabanayaan ischemia iyo hypoxia, laakiin sidoo kale waxay ka ilaalin kartaa xuubabka unugyada myocardial duulaanka xagjirrada xorta ah ee ogsijiinta iyo walxaha kale ee waxyeelada leh, taas oo saameyn karta shaqada wadnaha.Ilaalinta myocardial-ka-post-operative ee bukaannada qaba cudurka valvular-ka oo aan fiicnayn ayaa faa'iido u leh dib u soo kabashada shaqada wadnaha ee bukaannada qaba cudurka valvular ee aan fiicnayn.Isticmaalka si dhammaystiran loogu daweeyo dhaawaca myocardial ka dib neefta dhallaanka ah waxay si weyn u wanaajin kartaa enzymes myocardial myocardial iyo electrocardiogram, waxayna leedahay saameyn daaweyn iyo badbaado wanaagsan.

Astaamaha shaqada Alaabtani waa kaydka tamarta kiimikaad ee muruqyada wadnaha iyo lafaha, waxaana loo isticmaalaa dib-u-soo-celinta ATP, siinta tamar habka foosha actomyosin, waxayna door muhiim ah ka ciyaartaa dheef-shiid kiimikaadka tamarta murqaha foosha.Awood la'aanta tamarta ayaa ah arrin muhiim u ah samaynta iyo horumarinta dhaawaca unugyada myocardial.

1. Waxa ay saamayn weyn oo ilaalin ah ku leedahay shaqada ischemic myocardial systolic, kaas oo si buuxda u soo celin kara foosha oo si degdeg ah hoos ugu dhigi kara cadaadiska dhiigga ee diastolic.

2. Ilaali waxa ku jira adenosine triphosphate iyo phosphate creatine ee unugyada, iyo Kiimikada Buugu waxa uu ilaaliyaa kaydka tamarta myocardial.

3. Yaree luminta creatine kinase oo yarayso dhaawaca xuubka unugyada.

4. Waxay leedahay sifooyin anti-peroxidation.

5. Hagaajinta microcirculation myocardial.Sababtoo ah jiritaanka tamarta sare ee fosfooraska tamarta ee molecules phosphate creatine, bonds fosfateedka tamarta sare ayaa si toos ah u bedeli kara ADP ee ATP hoos yimaada ficilka phosphate creatine, oo si toos ah u siinaya tamarta jirka si uu isla markiiba u dhaqmo.Sida badeecada dhexdhexaadka ah ee glycolysis, sodium fructose diphosphate waxay u baahan tahay inay ka ciyaarto door aan toos ahayn iyada oo loo marayo dheef-shiid kiimikaadka anaerobic.

Jidka synthetic:

1 Isticmaalka fosfooraska dibenzyl sida walxo ceeriin ah, ku falcelisa oxalyl chloride si aad u hesho dibenzyl oxyphosphoryl chloride,

2 Marka la eego ficilka triethylamine, dibenzyloxyphosphoryl creatine ethyl ester oo ay heshay falcelinta creatine ethyl ester hydrochloride ayaa loo beddelaa dibenzyloxyphosphoryl creatinine,

3. Ka dib markii palladium carbon catalyzed hydrogenolysis si debenzylate, ka falceliso sodium hydroxide si aad u hesho disodium creatinine phosphate,

4 waxaa lagu shubaa 1 iyadoo hoos timaada falgalka sodium hydroxide.

Isticmaala: Waxay ku habboon tahay ilaalinta dheef-shiid kiimikaad aan caadi ahayn ee xaaladda ischemia myocardial.

Dareen-celinta xun, ka-hortagga iyo saameynta daroogada: kuwa xasaasiyadda ku leh qaybaha alaabtan waa mamnuuc;kuwa qaba kelyo-yarida joogtada ah waa ka mamnuuc inay isticmaalaan qiyaaso badan (5-10g/d).Duritaanka degdega ah ee xididada in ka badan 1g waxay sababi kartaa hoos u dhaca cadaadiska dhiigga.Maaraynta qiyaasta sare waxay keentaa qaadashada fosfooraska sare, taas oo saameyn karta dheef-shiid kiimikaadka calcium iyo dheecaanka hormoonnada ee xakameynaya homeostasis, saameynaya shaqada kelyaha iyo dheef-shiid kiimikaadka purine.