Alaabta

Firfircoonida trombobin-activatable fibrinolysis inhibitor (TAFIa) waa karboksipeptidase ka kooban zinc oo si weyn u joojiya fibrinolysis.Kahortagayaasha TAFIa ayaa sidaas awgeed laga filayaa inay u dhaqmaan sidii wakiilada profibrinolytic.Waxaan dhawaan soo sheegnay nakhshadeynta iyo isku-darka horjoogayaasha selenium-ka ku jira ee TAFIa iyo waxqabadkooda ka hortagga.Halkan waxaan ku soo gudbineynaa qaabdhismeedka crystal-ka ee selenium-, sulfur-, iyo fosfinic acid ka kooban inhibitors ee ku xiran porcine carboxypeptidase B (ppCPB).ppCPB waa TAFIa homologue waxayna u taagan tahay TAFIa falanqaynta crystallographic.Qaab dhismeedka kristal ee ppCPB oo ka kooban iskudhis selenium 1a, analooga sulfur 2, iyo fosfinic acid derivative EF6265 ayaa lagu go'aamiyay 1.70, 2.15, iyo 1.90 Å xallin, siday u kala horreeyaan.Horjooge kastaa wuxuu ku xidhaa goobta firfircoon ee ppCPB si la mid ah tii lagu arkay horjoogayaasha hore loo sheegay.Sidaa darteed, isku dhisyada, selenium, baaruud, iyo oksijiin aashitada fosfinic waxay isku dubbaridaan zinc gudaha ppCPB.Tani waa indha-indheynta iyo warbixinta ugu horraysa ee isku xirka selenium ilaa zinc ee CPB.