Alaabta

Bromelain (BR) waa borotiinka cysteine-ka oo leh saameyn liddi ku ah dheecaanka xiidmaha iyo bararka.Si kastaba ha ahaatee, saamaynta ay ku leedahay dhaqdhaqaaqa mindhicirka ayaa inta badan aan la sahamin.Sidaa daraadeed, waxaanu baadhnay saamaynta xaruntan ka soo jeeda dhirta ee qanjidhada mindhicirka iyo gaadiidka jiirarka. Contractility in vitro waxaa lagu qiimeeyay kicinta jiirka go'doonsan ee ileum, qubeyska xubinta taranka, oo leh acetylcholine, barium chloride, ama kicinta beerta korontada.Dhaqdhaqaaqa in vivo waxaa lagu cabiray iyadoo la qiimeeyay qaybinta calaamada fluorescent ee afka laga maamulo ee xiidmaha yar.Gaadiidka ayaa sidoo kale lagu qiimeeyay xaaladaha pathophysiologic ee ay keentay saliida korantada ee pro-bararka ama wakiilka diabetogenic streptozotocin.Bromelain waxay joojisay foosha oo ay keentay xeryahooda kala duwan ee spasmogenic ee ku yaala mouse ileum oo leh awood isku mid ah.Saamaynta antispasmodic-ka ayaa la yareeyay ama la dagaallamey xayndaabka enzyme proteolytic, gabexate (15 × 10 (-6) mol L (-1) , protease-activated r eceptor-2 (PAR-2) antagonist, N (1) -3 -methylbutyryl-N (4) -6-aminohexanoyl-piperazine (10 (-4) mol L (-1) , fosfolipase C (PLC) inhibitor, neomycin (3 × 10 (-3) mol L (-1) , iyo fosfodiesterase 4 (PDE4) inhibitor, rolipram (10 (-6) mol L (-1)).In vivo, BR waxay doorbidaysaa dhaqdhaqaaqa dhaqdhaqaaqa ee gobolada pathophysiologic hab PAR-2-antagonist-xasaasi ah. Xogtayadu waxay soo jeedinaysaa in BR ay joojiso dhaqdhaqaaqa xiidmaha - gaar ahaan xaaladaha pathophysiologic - oo leh hab suurtogal ah oo ku lug leh xuubka PAR-2 ​​iyo PLC iyo PDE4 sida intracellular calaamadaha.Bromelain waxay noqon kartaa xarun sun ah oo loogu talagalay horumarinta dawooyinka cusub, oo awood u leh inay caadi ka dhigto dhaqdhaqaaqa xiidmaha ee caabuqa iyo sonkorowga.