Alaabta

Bakteeriyada mindhicirka mindhicirka ee ginseng protopanaxadiol saponin, 20-O- (β-D-glucopyranosyl) -20 (S) -protopanaxadiol (compound K), ayaa lagu soo waramayaa inay keento apoptosis ee unugyada kansarka ee kala duwan.Si kastaba ha ahaatee, hababka saxda ah ee ay keentay isku dhafka K ee unugyada kansarka hepatocellular carcinoma (HCC) ayaan weli caddayn.Si loo baaro hababka suurtogalka ah ee apoptotic, waxaan baarnay saameynta ka hortagga kansarka ee K ee MHCC97-H.Qiimaynta MTT waxay muujisay in xarunta K ay joojisay kororka unugyada MHCC97-H oo leh sunta yar ee unugyada hepatoma ee caadiga ah.Horumarka wareegga unugyada iyo midabaynta unugga ayaa muujisay kororka jajab-hoosaadka apoptotic-G1.Daawaynta MHCC97-H oo leh xarun K waxay sidoo kale keentay hoos u dhac ku yimaada awoodda xuubka mitochondrial (Δψm) iyo dhaawaca DNA.Daraasad dheeraad ah ayaa muujisay in isku-dhafka K uu kor u qaaday Fas, FasL, Bax / Bcl-2 iyo hoos u dhigista pro-caspase-9, pro-caspase-3 qaab ku-tiirsanaan ah, iyo sidoo kale waxay joojisay fosforyaalka Akt.Natiijooyinkani waxay soo jeedinayaan in xarunta K ay si weyn u joojiso kororka unugyada oo ay keento apoptosis ee unugyada MHCC97-H iyada oo loo marayo Fas-iyo mitochondria-dhexdhexaadinta waddooyinka caspase-ku-tiirsan ee unugyada HCC ee bini'aadamka.