Alaabta

Chitosan-dextran jel ayaa loo isticmaalay sidii wakiilka dhiig-baxa iyo wakiilka ka-hortagga ka-hortagga qalliinka sinuska ka dib.Sababtoo ah Staphylococcus aureus biofilms ayaa lagu lug yeeshay rhinosinusitis daba-dheeraaday, daraasaddan ayaa loogu talagalay in lagu baaro (i) ka-hortagga caabuqa, (ii) bakteeriyada biofilm-ka-hortagga, (iii) saameynta antiproliferative, iyo (iv) guryaha bogsiinta boogaha ee chitosan iyo chitosan-dextran gel. Fibroblasts ayaa laga soocay unugyada sanka ee bini'aadamka waxaana loo isticmaalay si loo go'aamiyo saameynta chitosan iyo chitosan-dextran gel ee (i) faafinta unugyada, (ii) bogsashada dhaawaca, (iii) bararka dhaqamada fibroblast ee lagu loolamayo superantigens S. Aureus enterotoxin B (SEB) iyo sunta shoogga sunta (TSST), iyo (iv) ee S. aureus biofilms. Chitosan waxay aad waxtar ugu leedahay yaraynta muujinta IL-8 ka dib tartanka TSST iyo SEB.Chitosan waxay sidoo kale wax ku ool u ahayd yaraynta muujinta IL-8 ee fibroblasts-ka aan cidhiidhi ahayn ee muujinaya saamaynta ka-hortagga bararka ee fibroblasts ee gobolka ad seased.Chitosan-dextran jel waxay muujisay sifooyinka antibiofilm xooggan ee 50% (v / v) diiradda in vitro.Dextran, keligiis, wuxuu muujiyay sifooyinka antibiofilm ee 1.25% (w / v) diiradda.Chitosan, keligiis, hoos u dhigista fibroblasts ilaa 82% xakamaynta xakamaynta iyo chitosan-dextran jel waxay hoos u dhigtay faafinta fibroblasts ilaa 0.04% xakamaynta xakamaynta.Marka loo eego kontaroolada daawaynta la'aanta, gel chitosan-dextran ayaa si weyn u daahiyay heerka bogsashada nabarrada saacadaha 48 ee ugu horreeya ee tijaabada. muddo.Chitosan waxay hoos u dhigtay heerarka IL-8, taas oo muujinaysa sifooyinka anti-bararka.Chitosan-dextran jel iyo daawaynta dextran waxay muujisay sifooyinka antibiofilm ee qaabkayaga.