Albendazole Cas: 54965-21-8
| Lambarka buugaagta | XD91873 |
| Magaca Alaabta | Albendazole |
| CAS | 54965-21-8 |
| Qaabka molecularla | C12H15N3O2S |
| Miisaanka Molecular | 265.33 |
| Faahfaahinta Kaydinta | 2-8°C |
| Xeerka Tarifka La Iswaafajiyay | 29332990 |
Tilmaamaha Alaabta
| Muuqashada | Budada crystalline cad |
| Asay | 99% min |
| barta dhalaalaysa | 208-210 °C |
| cufnaanta | 1.2561 (Qiyaas adag) |
| index refractive | 1.6740 (qiyaas) |
| milmayn | Dhab ahaan aan biyo ku milmin, si xor ah ugu milmayn anhydrous formic acid, wax yar ku milmi kara methylene chloride, ficil ahaan aan lagu milmi karin ethanol (96 boqolkiiba). |
| pka | 10.72±0.10 (La saadaaliyay) |
| Biyo La'aanta | 0.75mg/L (209ºC) |
Albendazole waa daawo loo isticmaalo in lagu daweeyo caabuqyada ay sababaan dulin.Waxaa la siin karaa in lagu daweeyo caabuq maskaxeed naadir ah (neurocysticercosis) ama waxaa la siin karaa in lagu daweeyo caabuqa dulin ee keena shuban muhiim ah (microsporidiosis).
Kala soocida benzimidazole, albendazole waa daawo leh spectrum antihelmintic ballaaran.Waxay soo bandhigaysaa saameyn antihelmintic ah oo ka dhan ah cestodes xasaasiga ah iyo nematodes iyadoo xannibaysa habka qaadashada gulukooska ee dulinnada, taas oo lagu muujiyay hoos u dhaca kaydka glycogen iyo hoos u dhigista heerka adenosintriphophate.Natiijo ahaan, dulinku wuu joogsadaa dhaqdhaqaaqa wuuna dhintaa.Waxaa loo isticmaalaa marka caabuqa Acaris lumbricoides, Ancylostoma duodenale, Necator americanus, Enterobius vermicularis, iyo Trichuris trichiura.Ereyada la midka ah dawadan waa SKF 62979 iyo kuwa kale.
Methyl 5-(propylthio) -2-benzimidazolecarbamate (Eskazole,Zentel) waa anthelmintic ballaaran oo aan hadda laga iibin Waqooyiga Ameerika.Waxa laga heli karaa soo saaraha si naxariis leh.Albendazole ayaa si weyn looga isticmaalaa adduunka oo dhan si loogu daweeyo caabuqa mindhicirka.Waxay wax ku ool u tahay sida daawaynta hal-door ah ee ascariasis, caabuqyada hookworm-ka cusub iyo kan hore, iyo trichuriasis.Dawaynta qiyaasta badan ee albendazole waxay baabi'inaysaa pinworm, threadworm, capillariasis, clonorchiasis, iyo cudurka hydatid.Waxtarka albendazole ka-hortagga Gooryaanka (cestodes) guud ahaan waa isbeddel badan oo aan la dareemin.
Albendazole waxay u dhacdaa sida budo crystalline cad oo aan biyo ku milmi karin.Nuugista afka ee albendazoles ayaa lagu xoojiyay cunto dufan leh.Daawadu waxay martaa dheef-shiid kiimikaad hore oo degdeg ah oo ballaadhan oo loo diro sulfoxide, taas oo ah qaabka firfircoon ee plasma.Ciribtirka nolosha nuska ah ee sulfoxide waxay u dhexeysaa 10 ilaa 15 saacadood.Dib-u-warshadaynta biliary-ga ah iyo dib-u-warshadaynta enterohepatic ee albendazolesulfoxide ayaa dhacda.Albendazole guud ahaan si wanaagsan ayaa loogu dulqaatay daawaynta hal-door ee nematodes-ka mindhicirka.Qiyaasta sare, daawaynta daba dheeraatay ee looga baahan yahay daaweynta cudurka clonorchiasis orechinococcal waxay keeni kartaa saameyn xun sida niyad-jabka dhuuxa lafta, kor u qaadista enzymes beerka, iyo alopecia.
Albendazole waxay leedahay dhaqdhaqaaq balaadhan oo ka dhan ah nematodes mindhicirka iyo cestodes, iyo sidoo kale hargabka beerka Opisthorchis sinensis, Opisthorchis viverrini, iyo Clonorchis sinensis.Waxa kale oo si guul leh loogu isticmaalay Giardia lamblia.Albendazole waa daawaynta waxtarka leh ee cudurka cyst hydatid (echinococcosis), gaar ahaan marka lala socdo praziquantel.Waxa kale oo ay waxtar u leedahay daawaynta neerfaha maskaxda iyo laf-dhabarka neurocysticercosis, gaar ahaan marka la siiyo dexamethasone.Albendazole waxa lagula talinayaa in lagu daweeyo gnathostomiasis.
