Alaabta

Iyada oo ku saleysan ATP adenine, taxane adenine iyo derivatives purine ah ayaa la diyaariyey oo lagu tijaabiyay awooddooda si ay u xakameeyaan noocyo kala duwan oo kinases la xiriira cudurrada.Waxaa jiray cilmi baaris kooban oo lagu baarayay kartida cosubstrate-ka laga keenay kinase inhibitors ee kinase-yada kale ee aan ahayn CDK-yada.Naqshadeeyuhu wuxuu isku daray nidaamka purine-ka asalka ah ee cosubstrate ATP iyo phenyl moieties si loo sahamiyo isdhexgalka suurtagalka ah ee gobollada kala duwan ee goobta xiritaanka ATP ee dhowr kinases borotiinka la xiriira.Waxaa jiray tiro hits ah oo loogu talagalay walxaha la tijaabiyay, taas oo keentay in aan ku soo gabagabeyno in xajmiga xargaha laga yaabo inuu caddeeyo inuu yahay qalab qiimo leh oo loogu talagalay qiimeynta isku xirnaanta iyo qaababka xulashada ee noocyada kala duwan ee kinases.