Acriflavine, Cas dhexdhexaad ah: 8048-52-0 Orange ilaa casaan ilaa casaan-brown
| Lambarka buugaagta | XD90521 |
| Magaca Alaabta | Acriflavine, dhexdhexaad ah |
| CAS | 8048-52-0 |
| Qaanuunka molecular | C14H14ClN3 |
| Miisaanka Molecular | 259.73 |
| Faahfaahinta Kaydinta | Ambient |
| Xeerka Tarifka La Iswaafajiyay | 38249993 |
Tilmaamaha Alaabta
| Muuqashada | Orange ilaa casaan ilaa casaan-brown |
| Qiimayn | 99% |
| AS | ugu badnaan 10ppm |
| Khasaare xagga qallajinta | 8% ugu badnaan |
| Biyo aan milmi karin | 0.5% ugu badnaan |
| Dambaska sulfated | 3.5% ugu badnaan |
| Qiimaynta waxa ku jira koloriin la qalajiyey @ 105 Deg C ilaa 2 saacadood | 13.3 - 15.8% |
Inta badan daawooyinka ka hortagga kansarka ayaa ku guuldareysta inay ciribtiraan burooyinka, taasoo keenta horumarinta caabbinta daawada iyo soo noqoshada cudurrada.Calaamadaynta Hedgehog waxay ka ciyaartaa door muhiim ah inta lagu jiro koritaanka uurjiifka, laakiin sidoo kale waxay ku lug leedahay horumarinta kansarka, horumarka, iyo metastasis.Hedgehog receptor Patched (Ptc) waa hidde-sidaha bartilmaameedka hedgehog kaas oo si xad dhaaf ah loogu buufiyay unugyo badan oo kansar ah.Halkan, waxaan ku tusineynaa xiriirka ka dhexeeya Ptc iyo caabbinta kiimoterabiga, waxaana ku siineynaa aragti cusub oo ku saabsan shaqada Ptc.Ptc waa laga nadiifiyaa xuubka balasmaha marka lala falgalo ligand Hedgehog, ama marka lagu daweeyo unugyada leh cyclopamine-ka soo horjeeda ee Hedgehog.Labada xaaladoodba, ka dib markii la soo saaro unugyada leh doxorubicin, oo ah wakiilka kiimikaad ee loo isticmaalo maaraynta kiliinikada ee kansarrada soo noqnoqda, waxaan aragnay xannibaadda qulqulka doxorubicin ee fibroblasts-ka jawaab celinta Hedgehog, iyo korodhka isku-ururinta doxorubicin ee laba kansar oo kala duwan. xadhkaha gacanta ee loo yaqaan inay muujiyaan heerar qaylo-dhaanta qaybaha calaamadaha Hedgehog.Isticmaalka nidaamka muujinta heterologous, waxaanu si adag u muujinay in muujinta Ptc bini'aadanku ay keentay iska caabin ah joojinta koritaanka dawooyin dhowr ah kuwaas oo wakiilada kiimikaad sida doxorubicin, methotrexate, temozolomide, iyo 5-fluorouracil.Iska caabbinta doxorubicin waxay la xiriirtaa shaqada Ptc, sida lagu muujiyay iyadoo la adeegsanayo isbeddellada ka imanaya bukaannada Gorlin's syndrome taas oo saameynta dhexdhexaadinta Ptc ee calaamadaynta Hedgehog ay lumisay.Natiijooyinkayagu waxay muujinayaan in Ptc ay ku lug leedahay qulqulka daroogada iyo iska caabinta daawooyinka badan, waxayna soo jeedinaysaa in Ptc ay gacan ka geysato iska caabbinta kiimoterabiga ee unugyada kansarka.
