Alaabta

Shan iyo toban platinum(II) -kumbuyuutarrada ku salaysan biraha ayaa la sameeyay kuwaas oo ka faa'iidaysanaya beddelka 1,10-phenanthroline (phen), oo ay ku jiraan 5-chloro-1,10-phenanthroline (5-Cl-phen), 5-methyl-1,10- phenanthroline (5-CH3-phen), 5-amino-1,10-phenanthroline (5-NH2-phen), 5-nitro-1,10-phenanthroline (5-NO2-phen) iyo dipyrido [3,2-d : 2',3'-f] quinoxaline (dpq), iyo achiral ethylenediamine (en) iyo ligands chiral ancillary ligands 1S,2S-diaminocyclohexane (S, S-dach) iyo 1R,2R-diaminocyclohexane (R,R-dach) .Sitotoxicity-kooda ku jira khadka unugyada leukemia murine L1210 ayaa lagu go'aamiyay iyadoo la adeegsanayo tijaabooyinka xakameynta koritaanka.Iskudhisyada birta cytotoxic ee ugu badan waa kuwa ay ku jiraan S,S-dach ancillary ligands iyo 5-CH3-phen isku xirayaasha isku xira.Mid ka mid ah metallointercalator [Pt (5-CH3-phen) (S, S-dach)] Cl2 (5MESS), wuxuu muujinayaa koror 5-10 laab ah ee cytotoxicity marka la barbar dhigo wakiilka cisplatin.Laga soo bilaabo tijaabooyinka isku xidhka DNA-da ma muuqato farqi weyn oo u dhexeeya mid kasta oo ka mid ah dhismooyinka birta ah, taas oo muujinaysa in xidhiidhka DNA-da ama qaabka xidhidhiyaha/DNA-du aanu ahayn midka kaliya ee go'aamiya cytotoxicity ee qoyskan platinum(II) ku salaysan. metallointercalators.