Alaabta

The n-3 polyunsaturated fatty acids eicosapentaenoic acid (EPA) iyo docosahexaenoic acid (DHA) ayaa lagu muujiyay inay kor u qaadaan saamaynta dawooyinka chemotherapeutic ee daraasadaha kiliinikada ee bukaannada kansarka iyo inay keenaan dhimashada unugyada burooyinka apoptotic ee vitro.Ilaa hadda, EPA iyo DHA weligood laguma baarin myeloma badan (MM).Unugyada myeloma ee bini'aadamka (L363, OPM-1, OPM-2 iyo U266) iyo unugyada caadiga ah ee unugyada mononuclear-ka ee dhiigga ayaa la kulmay EPA iyo DHA, iyo saameynta shaqada mitochondrial iyo apoptosis, kicinta-3, muujinta hiddaha iyo sunta daroogada ayaa la qiyaasay.Soo-gaadhista EPA iyo DHA waxay keentay apoptosis iyo dareenka korodhka bortezomib ee unugyada MM.Muhiimad ahaan, ma aysan saameynin jiritaanka unugyada mononuclear-ka caadiga ah ee bini'aadamka.Nidaamyada muujinta Rasuulku RNA waxay muujiyeen in EPA iyo DHA hiddo-wadaha habaysan ee ku lug leh dariiqooyin calaamado badan oo ay ku jiraan factor nukliyeerka (NF) κB, Notch, Hedgehog, cadaadiska oksaydhka iyo Wnt.EPA iyo DHA waxay hakiyeen dhaqdhaqaaqa NFκB waxayna keeneen apoptosis iyada oo loo marayo qallafsanaanta mitochondrial iyo kaspase-3 firfircoonida.Daraasaddeenu waxay soo jeedinaysaa in EPA iyo DHA ay keenaan saamaynta cytotoxic ee MM iyo kordhinta dareenka bortezomib waxayna ku baaqaysaa sahaminta dheeraadka ah ee codsiga suurtagalka ah ee n-3 acids dufanka polyunsaturated ee daaweynta MM