Alaabta

(4R-Cis) -1,1-Dimethylethyl-6-[2-[2- (4-fluorophenyl) -5- (1-methylethyl) -3-phenyl-4-[(phenylamino) karbonyl] -1H-pyrrol -1-yl] ethyl] -2,2-dimethyl-1,3-dioxane-4-acetate waa xarun leh qaab dhismeed kiimiko oo adag.Inkasta oo macluumaadka gaarka ah ee isticmaalka xaruntan laga yaabo inay xaddidan tahay, waxaan ka wada hadli karnaa codsiyadeeda suurtagalka ah iyadoo lagu saleynayo sifooyinkeeda qaabdhismeed iyo sifooyin caadi ah oo isku mid ah. sida wakiilka milmaya.Dioxane waa dareere caadi ah, gaar ahaan kimistariga dabiiciga ah, maadaama ay tahay biyo-miscible waxayna leedahay milmayn wanaagsan oo noocyo badan oo unugyo organic ah.Joogitaanka moiety dioxane ee xaruntan waxay muujinaysaa in laga yaabo inay lahaato sifooyin milmayn oo isku mid ah. Intaa waxaa dheer, qaybaha qaabdhismeedka dhismahan, sida kooxaha fluorophenyl iyo phenylamino carbonyl, waxay soo jeedinayaan firfircoonida nafleyda.Beddelka fluorine ee xeryahooda dabiiciga ah waxay wanaajin kartaa hantidooda farmashiyaha, taasoo suurtogal ah inay kordhiso awooddooda ama helitaankooda noole.Joogitaanka kooxda phenylamino carbonyl waxay muujin kartaa suurtogalnimada isdhexgalka ee bartilmaameedyada bayoolojiga, oo laga yaabo inay keento saameynaha daweynta. Iyada oo ku saleysan sifooyinkaas qaabdhismeedka, waxaa suurtogal ah in xaruntani ay yeelan karto codsiyo ku saabsan kimisteriga daawada ama horumarinta daroogada.Waxa loo sahamin karaa inay noqoto sunta rasaasta suurtagalka ah ee horumarinta dawooyinka cusub ee lagu beegsanayo cudurro gaar ah.Si kastaba ha ahaatee, waxaa muhiim ah in la ogaado in daraasado dheeraad ah loo baahan yahay si loo go'aamiyo hantideeda dhabta ah ee farmashiyaha, oo ay ku jiraan waxtarkeeda, habka ficilka, iyo waxyeellooyinka ka iman kara. ama sida qayb ka mid ah isku dhafka kiimikada.Nitronyl iyo pyrrole derivatives ayaa lagu baadhay isticmaalkooda suurtagalka ah ee kirishbooyada organic, kicinta, ama baloogyada dhismaha ee dhismooyin aad u adag.Si kastaba ha ahaatee, codsiyadani waxay u baahan doonaan baaritaan dheeraad ah iyo hagaajinta hababka isku-dhafka ah. Guud ahaan, xarunta (4R-Cis) -1,1-Dimethylethyl-6-[2-[2- (4-fluorophenyl) -5- (1-) methylethyl -3-phenyl-4-[(phenylamino)carbonyl] -1H-pyrrol-1-yl] ethyl] -2,2-dimethyl-1,3-dioxane-4-acetate waxay muujineysaa suurtagalnimada codsiyada kimisteriga daawada, maaddooyinka sayniska, ama kiimikaad abuurka.Si kastaba ha ahaatee, waxaa muhiim ah in la sameeyo cilmi-baaris ballaaran si loo qiimeeyo hantideeda, loo horumariyo dariiqyo isku dhafan oo ku habboon, iyo go'aaminta codsiyadeeda gaarka ah ee goob kasta.