Alaabta

Isku-ururinta Submillimolar ee cytotoxic bile acids (BAs) waxay keentaa dhimashada unugyada iyada oo loo marayo apoptosis.Dhanka kale, dhowr BAs cytoprotective ah ayaa la muujiyay si ay uga hortagaan apoptosis ee kala duwanaansho isku mid ah.Weli, hababka ay BA-yadu u kiciyaan saamaynta calaamadahan iska soo horjeeda ayaan weli caddayn.Daraasaddan waxaa loogu talagalay in lagu go'aamiyo haddii cytotoxic iyo cytoprotective BAs, ee xoogga jireed ee firfircoon, ay awoodaan inay beddelaan sifooyinka biophysical ee xuubabka dufanka leh, oo laga yaabo inay u tarjumaan isbeddelada marinka apoptotic ee unugyada.Ku-xidhka BA-yada xuubabka waxaa lagu qiimeeyay kala duwanaanshaha cabirrada fluorescence ee BA-yada ku habboon.Ka-soo-baxyadan ayaa loo qaybiyay xidhiidh sare oo ka dhexeeya dareeraha khalkhalsan marka loo eego meelaha dareeraha ah ee kolesteroolka-ka ah ee la dalbaday.BA-yada aan la calaamadin ayaa sidoo kale la tusay inay leeyihiin meel sare marka la dhexgalo xuubka dufanka.Intaa waxaa dheer, isdhexgalka cytotoxic BAs ee leh xuubabka waxay keentay ballaarinta xuubka, sida laga soo xigtay xogta FRET.Waxaa intaa dheer, waxaa la muujiyay in cytotoxic BAs ay awoodeen inay si weyn u carqaladeeyaan amarka xuubka kolestaroolka ee uruurinta jir ahaaneed ee firfircoon ee BA, saameyn aan la xiriirin ka saarista kolestaroolka.Dhanka kale, cytoprotective bile acids wax saameyn ah kuma yeelan sifooyinka xuubka.Waxaa lagu soo gabagabeeyay, marka la eego saameynta la arkay ee adkeynta xuubka, dhaqdhaqaaqa apoptotic ee cytotoxic BAs ayaa laga yaabaa inay la xiriirto isbeddelada ururka xuubka plasma (tusaale wax ka beddelka qaybaha dufanka) ama kororka xuubka mitochondrial ee borotiinnada apoptotic.