Alaabta

4-Chloro-2-fluoro-3-methoxyphenylboronic acid waa unug kiimikaad ah oo leh codsiyo kala duwan oo ku jira isku-dhafka organic, chemistry, iyo sayniska alaabta. falcelinta isku-xidhka-isku-xidhka ee kala-guurka ee birta-catalyzed.Waxay u adeegtaa sida block dhiska boronic acid, taas oo u oggolaanaysa samaynta kaarboon-kaarboon ama curaarta kaarboon-heteroatom.Tusaale ahaan, xaruntan waxa loo isticmaali karaa falcelinta isku-xidhka Suzuki-Miyaura, halkaas oo ay kaga falcesho aryl ama vinyl halides oo hoos yimaada palladium catalysis si ay u abuurto xeryahooda biaryl.Dareen-celinta isku-tallaabta ah ayaa si ballaaran loogu shaqeeyaa isku-dhafka molecules organic adag, oo ay ku jiraan daawooyinka iyo agrochemicals, iyo sidoo kale dhismaha alaabta organic. Isku-dhafka gaarka ah ee chlorine, fluorine, iyo kooxaha methoxy ee qaabka 4-Chloro-2 -fluoro-3-methoxyphenylboronic acid waxay awood u yeelataa isku-dhafka noocyo kala duwan oo leh sifooyin gaar ah.Atomka koloriinku waxa uu u shaqayn karaa koox hagaya hababka kala-guurka ee birta-catalyzed, isaga oo u haga falcelinta si gooni ah goobo gaar ah oo ku dhex jira molecule.Beddelka fluorine wuxuu bixiyaa lipophilicity la xoojiyay, taas oo saameyn ku yeelan karta guryaha farmashiyaha ee xarunta oo wanaajin karta bioavailability.Kooxda methoxy, dhanka kale, waxay u dhaqmi kartaa sidii koox ilaalin ah ama waxay ka qayb qaadan kartaa isbeddello kiimikaad oo kala duwan. Kiimikada daawada, 4-Chloro-2-fluoro-3-methoxyphenylboronic acid iyo ka-soo-jeedadeedu waxay xiiseeyaan musharaxiinta daroogada ee suurtagalka ah.Kooxaha shaqeeya sida chlorine iyo fluorine waxay wax ka beddeli karaan isdhexgalka xarunta ee bartilmaameedyada bayooloji waxayna wanaajin karaan sifooyinkeeda dawooyinka.Intaa waxaa dheer, kooxda methoxy waxay wanaajin kartaa xasilloonida dheef-shiid kiimikaadka xarunta waxayna gacan ka geysataa lipophilicity iyo milanka.Guryahani waxay ka dhigayaan 4-Chloro-2-fluoro-3-methoxyphenylboronic acid bar bilow qiimo leh oo lagu horumarinayo wakiilada daweynta cusub ee beeraha sida kansarka, cudurada faafa, iyo caabuqa. Intaa waxaa dheer, boronic acid moiety in 4-Chloro-2-fluoro -3-methoxyphenylboronic acid waxay awood u siin kartaa samaynta esters boronate ah oo deggan, kuwaas oo loo adeegsaday naqshadaynta walxaha leh sifooyin gaar ah.Agabkani waxa ay soo bandhigi karaan muuqaalo, elegtaroonig ah, ama sifooyin katalytik ah, taas oo ku xidhan sida ay u samaysan yihiin iyo qaabdhismeedkooda.Isku-darka 4-Chloro-2-fluoro-3-methoxyphenylboronic acid ama waxyaabaha ay ka soo saartaan agabyadan waxay siin karaan hawlo gaar ah waxayna kor u qaadaan waxqabadkooda. iyada oo ay ugu wacan tahay kiimiko badan oo kala duwan iyo suurtogalnimada abuuritaanka molecules iyo agabka shaqaynaya.Doorka ay ku leedahay falcelinta isku xidhka birta-catalyzed ee kala guurka, oo ay weheliso sifooyinka gaarka ah ee kooxaheeda shaqaynaysa, ayaa ka dhigaysa qalab qiimo leh oo ku jira isku-dhafka dabiiciga ah iyo kimistariga daawada.Intaa waxaa dheer, unugyada boronic acid waxay awood u siinayaan samaynta boronate esters, taas oo gacan ka geysata horumarinta alaabta horumarsan oo leh sifooyin gaar ah.