4-Aminophthalhydrazide AMPPD Cas: 3682-14-2 Huruud fudud ilaa budo cagaaran oo madow si ay u buro
| Lambarka buugaagta | XD90156 |
| Magaca Alaabta | 4-Aminophthalhydrazide |
| CAS | 3682-14-2 |
| Qaanuunka molecular | C8H7N3O2 |
| Miisaanka Molecular | 177.16 |
| Faahfaahinta Kaydinta | Ku kaydi RT |
Tilmaamaha Alaabta
| Muuqashada | Huruud khafiif ah ilaa cambar ilaa budo cagaar madow si ay u soo bursato |
| Asay | ≥98.0% |
| Cufnaanta | 1.433 |
| barta dhalaalaysa | 300ºC |
| Barta karkarinta | 633°C at 760mmHg |
| Barta toosan | 336.7°C |
| Solubility | Ku milmay ammonium hydroxide, sodium carbonate ama saldhig kale. |
1.Waxaan falanqeeyay oo barbardhigay saamaynta shan H1-antihistamines on dillaaca oksaydhka ee dheeraadka ah-iyo intracellular heerka go'doonsan iyo kicin bini'aadamka polymorphonuclear leukocytes. qarxinta Oxidative ee neutrophils aadanaha go'doon ayaa lagu bartay by luminol iyo isoluminol wanaajiyey chemiluminescence. Kuwa soo socda Heerka awoodda H1-antihistamines si loo yareeyo chemiluminescence ayaa lagu qiimeeyay si ka baxsan unugyada: dithiaden> loratadine> chlorpheniramine> brompheniramine> pheniramine iyo goobta intracellular: loratadine> dithiaden.H1-antihistamines waxay ku kala duwan yihiin si aad ah iyadoo loo eegayo qaab dhismeedka kiimikada ee burppress ka baxsan labadaba. - iyo goobta intracellular ee neutrophils bini'aadamka la kiciyey ee go'doonsan.
Nidaamyada 2.Chemiluminescence ee la xoojiyay midkood isoluminol ama luminol marka lagu daro peroxidase waa habab xasaasi ah oo lagu ogaanayo noocyada oksijiinta falcelinta (ROS) ee ay soo saarto phagocyte NADPH oxidase.Labada substrate-ka-weynaynta ayaa qaab-dhismeed ahaan isku mid ah, ku kala duwan yihiin kaliya booska kooxda amino ee giraanta udgoonka ee molecules-ka.Farqigani waxa uu ka dhigayaa isoluminol unug lipophilic ah oo ka yaraada xuubabka noolaha.Isticmaalka isoluminol ayaa sidaa awgeed ku xaddidan daraasadaha la tacaalaya dheecaanka dheef-shiid kiimikaadka oksijiinta.Daraasaddan waxaan ku muujineynaa in peptides synthetic oo ka soo jeeda N-terminal domain ee kalsiyum-ku-habboon borotiinka annexin AI waxay farageliyaan ogaanshaha xagjirnimada ee isoluminol-la xoojiyay, laakiin aan ku jirin nidaamka luminol-la xoojiyay.peptides-ka annexin AI-derived peptides wuxuu yareeyaa soosaarka iftiinka leh isoluminol oo ku faraxsan superoxide iyo horseradish peroxidase (HRP) ee formyl-methionyl-leucyl-phenylalanine- iyo phorbol my ristate acetate-kicinta unugyada, iyo sidoo kale by hydrogen peroxide iyo HRP.Habka saxda ah ee xannibaadda lama yaqaan.Natiijooyinka la soo bandhigay waxay si xoog leh u soo jeedinayaan in jawaab celinta gacanta ee la dhimay ee lagu ogaaday kiimikooyinka isoluminol-amplified chemiluminescence waa in lagu xaqiijiyo farsamo kale si loo go'aamiyo sii daynta anions superoxide iyo hydrogen peroxide.
