Alaabta

4- (4-Fluorophenyl) -6-Isopropyl-2-[(N-Methyl-N-Methylsulfonyl) Amino] Pyrimidinyl-5-Yl-Formyl, oo sidoo kale loo yaqaan FIMPA, waa isku-dhafan kiimiko oo leh qaab dhismeed adag oo leh karti. codsiyada cilmi-baarista dawooyinka iyo horumarinta daroogada.Waxaa loo kala saaraa sida derivative pyrimidine oo leh koox formyl ah oo ku xiran atamka carbon 5, iyo 4-fluorophenyl iyo koox isopropyl ah oo ku xiran atamka 4th iyo 6th, siday u kala horreeyaan. Mid ka mid ah codsiyada muhiimka ah ee FIMPA ayaa ku jira berrinka cilmi-baarista kansarka.Soosaarayaasha Pyrimidine ayaa si aad ah loo darsay sifooyinkooda antitumor, FIMPA waxay muujineysaa suurtagalnimada wakiilka kansarka ka hortagga.Sifooyinkeeda qaabdhismeedku waxay ka dhigaan musharax rajo leh oo lagu joojinayo enzymes-yada muhiimka ah ama receptors ee ku lug leh koritaanka iyo horumarka burada.Cilmi-baarayaashu waxay wax ka beddeli karaan qaab-dhismeedka FIMPA si ay u kordhiyaan awooddeeda, xulashada, iyo guryaha farmashiyaha si loogu daaweeyo kansarka waxtarka leh. Intaa waxaa dheer, FIMPA waxay sidoo kale u dhaqmi kartaa sidii muraayad molecular oo loogu talagalay horumarinta musharaxiinta daroogada ee lagu beegsanayo cudurrada kale.Qaab dhismeedkeeda gaarka ah ayaa u oggolaanaya in lagu xidho kooxo kala duwan oo shaqaynaya, kuwaas oo door muhiim ah ka ciyaari kara la falgalka bartilmaameedyada molecular ee gaarka ah.Kala duwanaanshiyahani wuxuu FIMPA ka dhigayaa qalab qiimo leh oo ku jira kimistariga daawada si loo horumariyo wakiilada daweynta cusub ee ka hortagga cudurrada kala duwan sida xanuunada neerfaha ama cudurrada faafaKooxaheeda firfircoon ee firfircoon, sida kooxaha formyl iyo sulfonyl, waxay u adeegi karaan sidii goobo wax ka bedel kiimiko oo dheeraad ah.Cilmi-baadhayaashu waxay isticmaali karaan FIMPA sida qalab bilow ah ama dhexdhexaad dhexdhexaad ah si ay u helaan noocyo kala duwan, kuwaas oo lagu baari karo dhaqdhaqaaqyadooda bayoolojiga ama loo isticmaalo sidii dhismo dhismo oo loogu talagalay isku-dhafka molecules kakan. Guud ahaan, 4- (4-Fluorophenyl) -6-Isoropyl -2-[(N-Methyl-N-Methylsulfonyl) Amino] Pyrimidinyl-5-Yl-Formyl (FIMPA) waxay soo bandhigtaa karti rajo leh oo ku saabsan qaybaha kala duwan ee cilmi-baarista dawooyinka iyo horumarinta daroogada.Qaab-dhismeedkeeda gaarka ah iyo kooxaha shaqeeya waxay ka dhigaan qalab muhiim ah oo loogu talagalay naqshadeynta musharraxiinta daroogada cusub ama isku-dhafka isku-dhafka dabiiciga ah ee adag.Sahaminta dheeraadka ah iyo wanaajinta guryaha FIMPA waxay u horseedi kartaa helitaanka dawooyinka cusub ee cusub waxayna gacan ka geysataa horumarinta dhinaca kimistariga daawada.