Alaabta

Acetoxy Empagliflozin, oo sidoo kale loo yaqaan empagliflozin acetate, waa nooc la beddelay oo ah dawada ka hortagga sokorowga empagliflozin.Empagliflozin waxay ka tirsan tahay dawooyinka loo yaqaanno sodium-glucose co-transporter 2 (SGLT2) inhibitors, kuwaas oo inta badan loo isticmaalo maaraynta nooca 2 ee sonkorowga mellitus.Iyadoo la joojinayo borotiinkan, (3R,4S,5R,6R) -3,4,5-tris(triMethylsilyloxy) -6-((triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-mid waa kiimiko isku dhafan oo leh magaca kiimikaad dheer.Waxay ku dhacdaa fasalka triMethylsilyloxy pyranones, kuwaas oo si weyn loogu isticmaalo codsiyada sayniska iyo warshadaha kala duwan.One ka mid ah isticmaalka muhiimka ah ee (3R,4S,5R,6R) -3,4,5-tris(triMethylsilyloxy) -6-( (triMethylsilyloxy) Methyl) tetrahydro-2H-pyran-2-mid waa sida koox ilaalin ah oo ku jirta isku-dhafka dabiiciga ah.Kooxaha ilaalinaya waa kooxo shaqaynaya oo ku meel gaadh ah oo loo isticmaalo in lagu ilaaliyo goobo falcelineed oo gaar ah oo ku jira molecule inta lagu jiro fal-celinta kiimikada.Marka laga hadlayo (3R,4S,5R,6R) -3,4,5-tris(triMethylsilyloxy) -6-((triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one, kooxaha triMethylsilyloxy waxay u dhaqmaan sidii unug ilaalin ah. .Inta lagu jiro falcelinta, kooxahani waxay ka difaacaan kooxaha shaqeeya qaarkood inay ku dhacaan falcelin aan loo baahnayn, taasoo u oggolaanaysa falcelinta la doonayo inay si habsami leh u socoto.Ka dib marka falcelinta la dhammeeyo, kooxaha triMethylsilyloxy si fudud ayaa looga saari karaa, oo muujinaya kooxaha asalka ah ee shaqeynaya. Isticmaalka kale ee (3R,4S,5R,6R) -3,4,5-tris Methyl) tetrahydro-2H-pyran-2-mid waxay ku jirtaa isku dhafka isku dhafka dabiiciga ah.Waxaa loo isticmaali karaa sidii dhisme dhisme si loo dhiso dhismayaal aad u adag.Sifooyinkeeda kiimikaad ee gaarka ah iyo falcelinta waxay ka dhigtaa qalab qiimo leh oo lagu horumarinayo qaybaha kiimikada cusub.Chemists waxay isticmaali karaan (3R,4S,5R,6R) -3,4,5-tris(triMethylsilyloxy) -6-((triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-mid si ay u soo bandhigaan kooxo gaar ah oo shaqaynaya ama abuuraan molecular gaar ah scaffolds si ay u bartaan hawlaha bayooloji ee xeryahooda ama ay horumariyaan daawooyin cusub. Intaa waxaa dheer, xarunta this laga yaabaa in la helo codsiyada berrinkii sayniska alaabta.Joogitaankeeda koox shaqaynaysa oo ku jirta molecule waxay siin kartaa waxyaabo gaar ah oo la doonayo alaabta.Tusaale ahaan, waxay kor u qaadi kartaa milanka dareerayaasha gaarka ah ama waxay hagaajin kartaa guryaha samaynta filimada, taas oo ka dhigaysa mid faa'iido u leh dahaarka ama dhejiska.(3R,4S,5R,6R) -3,4,5-tris triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-mid waa iskudhis aad u khaas ah oo loo isticmaalo qaybaha kala duwan ee sayniska iyo warshadaha.Awoodda ay u leedahay in ay u dhaqmaan sidii koox ilaalin ah oo u adeegta sida dhismaha dhismaha kiimikada synthetic, iyo sidoo kale codsigeeda suurtagalka ah ee sayniska maadiga ah, waxay ka dhigtaa qayb qiimo leh oo horumarinta molecules iyo qalabka cusub.Si kastaba ha ahaatee, adeegsigeeda saxda ah iyo adeegsigeeda way kala duwanaan kartaa, iyadoo ku xidhan shuruudaha gaarka ah iyo yoolalka mashruuc saynis ama warshadeed gaar ah.