Alaabta

(3R,4R) -1- (tert-Butoxycarbonyl) -4-methylpyrrolidine-3-carboxylic acid, sidoo kale loo yaqaan Boc-4-methylproline, waa xarun kiimiko ah oo si weyn loogu isticmaalo goobta isku-dhafka dabiiciga ah, gaar ahaan soosaarka peptides iyo peptidomimetics ee codsiyada kala duwan.Mid ka mid ah isticmaalka ugu muhiimsan ee Boc-4-methylproline waa koox ilaalin ah oo loogu talagalay kooxda amino acids amino inta lagu jiro isku-dhafka peptide.Kooxaha ilaalinaya waa isbedel ku meel gaar ah oo gaashaanka u ah kooxo gaar ah oo shaqeynaya oo molecules si ay uga hortagaan falcelinta aan loo baahnayn inta lagu jiro habka synthetic.Isku-dhafka peptide, Boc-4-methylproline waxaa loo shaqeeyaa sidii koox ilaalin ah oo loogu talagalay kooxda amine, taas oo u oggolaanaysa in lagu xiro asiidhyada kale ee amino acids si ay u sameeyaan taxanaha peptide-ka ee la rabo. isku dhafka xeryahooda kala duwan oo leh hawlo bayooloji oo suurtagal ah.Iskudhis-kiral ahaan, waxay leedahay isteerinka isteerinka, taasoo keenaysa laba soo-dhaliye: (3R,4R) -Boc-4-methylproline iyo (3S,4S) -Boc-4-methylproline.Enantiomer kasta waxa laga yaabaa inuu soo bandhigo sifooyin dawooyin kala duwan iyo isdhexgalka bartilmaameedyada noolaha.Adigoo isticmaalaya Boc-4-methylproline oo ah walxo bilaw ah, farmashiyeyaashu waxay heli karaan noocyo kala duwan oo ka mid ah xeryahooda chiral si ay u helaan daroogada iyo horumarinta.Iskudhisyadaan ayaa lagu baaray awoodooda inay yihiin wakiilo daweyn ah oo ka dhan ah cudurada kala duwan, oo ay ku jiraan bakteeriyada, fayrasyada, iyo unugyada kansarka.Iyadoo la bedelayo qaabka Boc-4-methylproline iyo qiimeynta asalkeeda, cilmi-baarayaashu waxay sahamin karaan awooddooda sida xayndaabyada rasaasta ama molecules molecules ee naqshadeynta daroogada.Marka lagu daro codsiyadeeda isku-dhafka peptide iyo horumarinta daroogada, Boc-4-methylproline ayaa sidoo kale la shaqeeyaa. abuurista peptidomimetics.Peptidomimetics waa isku-dhisyo u ekeeya qaab-dhismeedka iyo shaqada peptides-ka laakiin leh xasilloonida iyo guryaha farmashiyaha.Boc-4-methylproline waxay u adeegi kartaa sidii dhisme dhisme ah oo ku saabsan naqshadeynta iyo isku-dhafka peptidomimetics, taas oo u oggolaanaysa horumarinta daweynta cusub ee bioavailability la wanaajiyey iyo gaar ahaan bartilmaameedka. 4-methylpyrrolidine-3-carboxylic acid, ama Boc-4-methylproline, waa xayndaab kala duwan oo si ballaaran loogu isticmaalo isku-dhafka dabiiciga ah.Doorkeeda sida kooxda ilaalinta ee isku-dhafka peptide, iyo sidoo kale sifooyinka chiral, waxay ka dhigtaa dhismo qiimo leh oo loogu talagalay abuurista peptides, peptidomimetics, iyo xeryahooda chiral.Ka-soo-saareyaasha Boc-4-methylproline waxaa lagu baaraa hawlahooda bayooloji ee suurtagalka ah, kuwaas oo ay ku jiraan antimicrobial, fayraska, iyo guryaha kansarka.Cilmi-baarista joogtada ah iyo hal-abuurka ee isticmaalka Boc-4-methylproline ee naqshadaynta daroogada waxay gacan ka geysataa horumarinta wakiilada daweynta cusub waxayna hagaajinaysaa fahamka hababka bayoolojiga ee adag.