Alaabta

(3aR. qaab dhismeed gaar ah oo isku siinaya dhowr adeegsi oo suurtagal ah oo ku saabsan kiimikooyinka daawada iyo horumarinta daroogada. Mid ka mid ah codsiga suurtagalka ah ee BISO ayaa ku jira daaweynta xanuunada neerfaha.Joogitaanka unugyada benzo [d] isothiazol-3-yl ee qaab-dhismeedkeeda waxay soo jeedinaysaa in BIS laga yaabo inay la falgasho nidaamyada neurotransmitter ee maskaxda, sida hababka glutamate ama GABAergic.Nidaamyadan neurotransmitter-ka ayaa ku lug leh xanuuno badan oo neerfaha sida suuxdin, walaac, iyo xanuunada niyadda.Cilmi-baadhayaashu waxay sahamin karaan awoodda BISO si ay u habeeyaan nidaamyadan oo ay u horumariyaan wakiilada daweynta cusub ee xaaladaha neerfaha. Intaa waxaa dheer, BIS's spiro[isoindole-2,1-piperazin] qaab-dhismeedka asaasiga ah ayaa awood u leh isticmaalka horumarinta daawooyinka lagu beegsanayo tiro balaadhan oo ah bartilmaameedyada nafleyda.Qaabkeeda saddex-geesoodka ah iyo joogitaanka kooxaha shaqeynaya waxay la falgeli karaan soo-dhoweeyayaal gaar ah ama enzymes, taas oo u oggolaanaysa naqshadaynta dawooyinka xulashada iyo awoodda leh.Cilmi-baadhayaashu waxay ka faa'iideysan karaan qaabkan qaab-dhismeedka si ay u horumariyaan molecules yaryar kuwaas oo bartilmaameedsanaya soo-qabayaasha ku lug leh cudurrada kala duwan, sida kansarka, cudurrada wadnaha, ama cudurrada faafaJoogitaanka koox la soo dacweeyay ayaa u oggolaanaysa in la sameeyo dhismayaal ionic ah oo leh unugyo si xun loo dallacay, sida asiidhyada nucleic ama borotiinada.Dhismayaashani waxay fududeyn karaan gaarsiinta bartilmaameedka ah ee unugyada bioactive ee unugyo gaar ah ama unugyo, kor u qaadista waxtarka daaweynta iyadoo la yareynayo dhibaatooyinka nidaamka. Waxaa xusid mudan in codsiyada suurtagalka ah ee BISO ay yihiin kuwo mala-awaal ah oo u baahan cilmi-baaris iyo horumarin dheeraad ah.Qaab dhismeedkeeda gaarka ah waxa uu soo bandhigayaa fursadaha farmashiyeyaasha dawooyinka si ay u sahamiyaan astaamaheeda dawada oo ay u wanaajiyaan awoodeeda helitaanka daawada. Sida xarun kasta oo kiimiko ah, isticmaalka BISO waa in uu u hoggaansamo hab-maamuuska badbaadada iyo hab-raacyada.Cilmi-baadhayaashu waa inay taxaddar muujiyaan inta lagu jiro isku-dhafka, maaraynta, iyo kaydinta si loo hubiyo badbaadada oo loo yareeyo khatarta. Gabagabadii, (3aR,7aR) -4-(benzo [d] isothiazol-3-yl) octahydrospiro[isoindole-2,1-piperazin ] -2-ium4-methylbenzenesulfonate, ama BISO, waxay haysaa ballanqaad codsiyo kala duwan oo ku saabsan kimistariga daawada iyo horumarinta daroogada.Qaab-dhismeedkeeda gaarka ah ayaa bixiya fursadaha helitaanka dawooyinka cusub ee daaweynta, hababka gudbinta daroogada ee la beegsanayo, iyo habaynta hababka neurotransmitter.Si kastaba ha ahaatee, cilmi-baaris ballaaran ayaa lagama maarmaan u ah in si buuxda loo caddeeyo awooddeeda oo loo wanaajiyo isticmaalkeeda dhinaca daawada.