Alaabta

(2S,5S)-5-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-oxo-1,2,4,5,6,7-hexahydroazepino[3,2,1] -hi]indole-2-carboxylic acid, aynu u tixraacno sida Compound X, waa unugyo dabiici ah oo kakan oo leh codsiyo suurtagal ah oo ku saabsan kimisteriga daawada iyo helitaanka daroogada.Qaab dhismeedkeeda gaarka ah waxa uu isku daraa qaybaha azepine, indole, iyo fluorene, isaga oo siinaya fursado hawlo kala duwan oo bayooloji ah iyo codsiyo daweyn.Kooxahani waxay awood u siinayaan isdhexgalka suurtagalka ah ee bartilmaameedyada noolaha.Xaruntu waxay u adeegi kartaa sidii barta bilawga ah ee isku-dhafka iyo hagaajinta xeryahooda sunta rasaasta ee barnaamijyada daahfurka daroogada. Mid ka mid ah codsiga suurtagalka ah ee Compound X waxay ku jirtaa sifooyinka antimicrobial.Joogitaanka kooxda fluorene, oo loo yaqaan waxqabadkeeda antimicrobial, waxay soo jeedinaysaa in xaruntani ay suurtogal tahay in ay hor istaagto korriinka bakteeriyada cudurada keena ee kala duwan sida bakteeriyada, fangaska, ama dulinnada.Iyadoo wax laga beddelayo qaab-dhismeedka Compound X, saynisyahannadu waxay hagaajin karaan sifooyinkooda antimicrobial waxayna wanaajiyaan doorashadooda ka dhanka ah cudur-sidaha gaarka ah. Intaa waxaa dheer, qaabka gaarka ah ee Compound X wuxuu ka dhigi karaa musharax suurtagal ah horumarinta daawada kansarka.Xeryahooda ku salaysan Indole waxay muujiyeen waxqabad ka dhan ah noocyada kansarka ee kala duwan, iyagoo u dhaqmaya sidii horjoogayaasha dariiqyada calaamadaynta gaarka ah ee ku lug leh faafinta unugyada kansarka iyo badbaadada.Ku darida azepine iyo fluorene moieties ee Compound X waxay kor u qaadi kartaa waxtarkeeda iyo xulashada wakiilka ka hortagga kansarka.Cilmi-baadhayaashu waxay sahamin karaan awoodda Compound X oo ah sunta rasaasta waxayna horumariyaan waxyaabo ka soo jeeda kuwaas oo soo bandhigaya waxqabadka ka hortagga kansarka oo la wanaajiyey iyo sunta oo yaraatay. Intaa waxaa dheer, Compound X waxaa laga yaabaa in lagu baaro awooddeeda sida wakiilka neuroprotective.Qaybaha fluorene iyo azepine waxay muujiyeen sifooyinka neuroprotective ee cilmi-baaris hore.Dhismaha xaruntan wuxuu ka dhigayaa musharax xiiso leh oo loogu talagalay sahaminta dheeraadka ah ee daaweynta cudurrada neurodegenerative, sida Alzheimers ama cudurka Parkinson.Iyadoo la fahmayo hababka ficilka iyo wax ka beddelka Compound X si waafaqsan, cilmi-baarayaashu waxay awood u yeelan karaan inay horumariyaan waxqabadyo daweyn si looga hortago ama loo yareeyo horumarka cuduradan daciifka ah. -yl)methoxy)carbonyl)amino)-4-oxo-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indole-2-carboxylic acid, ama Compound X, waxa uu hayaa awood weyn dhanka kimisteriga daawada iyo daawaynta.Qaab dhismeedkeeda molecular ee gaarka ah ayaa bixiya fursadaha horumarinta wakiilada antimicrobial, daawooyinka kansarka, iyo xeryahooda neuroprotective.Cilmi-baaris dheeraad ah, wax-ka-beddelid, iyo hagaajinta Compound X waxay daaha ka qaadi kartaa awooddeeda daweynta buuxda, taasoo horseedaysa horumarinta dawooyin cusub oo loogu talagalay daaweynta cudurrada kala duwan.