Alaabta

Xarunta (2S, 3R, 4S, 5S, 6R) -2- (3- (4- ((S)) -tetrahydrofuran-3-yloxy) benzyl -4-chlorofenyl -tetrahydro-6- (hydroxymethyl) -2 -methoxy-2H-pyran-3,4,5-triol waa unug dabiici ah oo adag oo leh codsiyada suurtagalka ah ee dhinacyo kala duwan, oo ay ku jiraan farmashiyaha iyo kimistariga. oo leh giraan kale oo pyran ah.Joogitaanka stereocenters badan ee qaab-dhismeedkeeda waxay ka dhigaysaa unugyo chiral ah, taasoo la macno ah inay ku jirto laba nooc oo enantiomeric ah oo yeelan kara hawlo bayooloji oo kala duwan. Mid ka mid ah codsiga suurtagalka ah ee xaruntan ayaa ku jirta helitaanka iyo horumarinta daroogada.Astaamaha qaabdhismeedka molecule, sida kooxaha benzyl iyo chlorophenyl, oo ay weheliso joogitaanka kooxo badan oo hydroxyl ah, waxay soo jeedinayaan inay muujin karto dhaqdhaqaaqa noolaha.Farmashiistaha dawooyinka ayaa sahamin kara awoodda xarunta sida xarun horseed u ah horumarinta dawooyinka cusub, gaar ahaan kuwa lagu beegsanayo cudurrada ku lug leh dheef-shiid kiimikaadka karbohaydraytyada. Joogitaanka kooxda (S) -tetrahydrofuran-3-yloxy waxay soo jeedinaysaa in xaruntu ay awood u leedahay inay is dhex gasho. oo leh reseptors ama enzymes oo ku lug leh dheef-shiid kiimikaad karbohaydrayt ama waddooyinka calaamadaynta.Cilmi-baadhayaashu waxay baari karaan awooddeeda sidii horjooge ama modulator ee enzymes gaar ah ama soo-dhoweeyayaasha ku lug leh hababkan.Intaa waxaa dheer, kakanaanta qaabdhismeedka xarunta ayaa laga yaabaa inay ka dhigto musharrax ku habboon hagaajinta kimistariga daawada iyada oo loo marayo wax ka beddelka qaabdhismeedka. Intaa waxaa dheer, xargaha xargaha ee pyranopyran ayaa ka kooban kooxo badan oo hydroxyl ah, kuwaas oo ah kooxo muhiim ah oo shaqeynaya naqshadeynta daroogada.Kooxaha Hydroxyl waxay ka qayb qaadan karaan isdhexgalka isku xidhka haydarojiin, iyagoo saamaynaya milanka xarunta, xasiloonida, iyo guryaha farmashiyaha.Farmashiyeyaasha dawooyinka ayaa ka faa'iidaysan kara kooxahan si ay u wanaajiyaan awoodda xarunta, xulashada, iyo sifooyinka kale ee dawooyinka.Habaynteeda gaarka ah ee kooxaha shaqaynaya waxa loo isticmaali karaa isku xidhka xeryahooda organic cusub oo leh sifooyin gaar ah ama shaqayn.Intaa waxaa dheer, xaruntu waxay u adeegi kartaa bilawga horumarinta alaabta cusub, sida polymers ama qaababka supramolecular, oo leh codsiyada suurtagalka ah ee warshadaha kala duwan. Gabagabadii, xarunta (2S, 3R, 4S, 5S, 6R) -2- (3- (4- ((S) -tetrahydrofuran-3-yloxy) benzyl -4-chlorophenyl -tetrahydro-6- (hydroxymethyl) -2-methoxy-2H-pyran-3,4,5-triol waxay leedahay qaab dhismeed sifooyin ka dhigaya mid waxtar u leh kimisteriga dawada iyo daawaynta, sayniska agabka, iyo isku-dhafka organic.Qaab dhismeedkeeda kakan iyo kooxo kala duwan oo shaqaynaya ayaa bixiya fursadaha sahaminta daawaynta, habaynta enzyme, horumarinta agabka, iyo meelaha kale ee cilmi baadhista.