Alaabta

Xarunta (2S,3R,4R,5S,6R) -2-[4-Chloro-3- (4-ethoxybenzyl) phenyl] -6- (hydroxymethyl) tetrahydro-2H-pyran-3,4,5-triol waa molecule organic adag oo leh codsiyo muhiim ah oo ka iman kara beeraha kimisteriga iyo farmashiyaha.Joogitaanka kooxaha chloro, ethoxybenzyl, iyo hydroxymethyl waxay siisaa fursad lagu sahamiyo isdhexgalka xarunta ee bartilmaameedyada bayoolojiga iyo qiimeynta awoodeeda sida wakiilka daweynta.Qaab dhismeedka xaruntu waxa ay soo jeedinaysaa in laga yaabo in ay yeelato hawlo dawooyin ah ama ay muujin karto suurtogalnimada helitaanka daroogada.Cilmi-baadhayaashu waxay samayn karaan daraasado kala duwan, oo ay ku jiraan in vitro iyo in vivo tests, si ay u qiimeeyaan xarunta dhaqdhaqaaqa noolaha, habka ficilka, iyo awoodda daaweynta.Qalabaynta gaarka ah ee xarunta, oo leh isku-dhafan S iyo R, ayaa laga yaabaa inay gacan ka geysato dhaqdhaqaaqeeda bayooloji, taasoo ka dhigaysa unug xiiso leh baaritaan dheeraad ah. Intaa waxaa dheer, qaabka adag ee xaruntu waxay bixisaa fursado loogu talagalay kiimikada dabiiciga ah ee dabiiciga ah.Cilmi-baadhayaashu waxay u isticmaali karaan xaruntan sidii qalab bilow ah oo loogu talagalay isku-dhafka molecules aadka u adag ama waxyaabaha dabiiciga ah ee dabiiciga ah.Samaynta waxka bedelka xulashada molecule's molecule's functionalities, farmashiyeyaashu waxay heli karaan isku-dhisyo leh sifooyin la rabo, sida waxtarka dawooyinka oo la hagaajiyay, milanka la xoojiyey, ama sunta oo yaraatay.Joogitaanka kooxda hydroxymethyl waxay fureysaa suurtagalnimada isbeddello dheeraad ah, sida u beddelashada kooxo kala duwan oo shaqeynaya, taas oo u oggolaanaysa diyaarinta maktabad kala duwan oo xeryahooda ah oo loogu talagalay codsiyada kala duwan. Intaa waxaa dheer, awoodda dhismaha ee dhismaha dhisme chiral ee isku-dhafka asymmetric. waa in aan la ilduufin.Joogitaanka xarumo badan oo chiral ah oo ku jira molecule waxay u oggolaaneysaa diyaarinta xeryahooda enantiomerically saafi ah, kuwaas oo muhiim u ah warshadaha dawooyinka.Farmashiyeyaasha dabiiciga ah waxay sahamin karaan utility xarunta si loo dhiso molecules chiral adag, taas oo keeni karta in la helo dawooyin cusub ama horumarinta hababka cusub ee synthetic. Waxaa muhiim ah in la ogaado in la shaqaynta xaruntan u baahan tahay khibrad xagga maaraynta iyo soo saarista molecules organic adag.Cilmi-baarayaashu waa inay taxaddaraan oo ay raacaan borotokoolka badbaadada ku habboon inta lagu jiro dhammaan geeddi-socodka oo dhan, laga bilaabo isku-dhafka ilaa sifaynta iyo maaraynta. phenyl] -6- (hydroxymethyl) tetrahydro-2H-pyran-3,4,5-triol waxay soo bandhigaysaa karti la taaban karo oo ku jirta kimistari daawaynta, kiimikooyinka dabiiciga ah ee synthetic, iyo isku-dhafka asymmetric.Qaab-dhismeedkeeda gaarka ah iyo stereochemistry waxay furaan waddooyin lagu fahmo hawlaheeda bayooloji, qaabaynta wakiillada daweynta cusub, iyo horumarinta xeeladaha synthetic ee abuurista molecules organic kakan.Sahaminta joogtada ah ee guryaha iyo codsiyada xaruntan ayaa laga yaabaa inay gacan ka geysato horumarinta daroogada, isku dhafka kiimikada, iyo fahamka hababka noolaha.