Alaabta

2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone (TMS-D-glucose lactone) waa unug kiimiko ah oo caan ku ah codsiyada ku jira isku-dhafka dabiiciga ah, gaar ahaan qaybta kiimikada karbohaydraytyada.Waa nooc ka mid ah D-glucose, sonkor si dabiici ah u dhacda, waxayna leedahay sifooyin gaar ah oo faa'iido u leh falcelinta kiimikaad ee kala duwan. Mid ka mid ah isticmaalka aasaasiga ah ee TMS-D-glucose lactone waa koox ilaalinaysa kiimikada karbohaydraytyada.Carbohydrates, oo ay ku jiraan sonkorta, waxay yeelan karaan kooxo badan oo hydroxyl ah, kuwaas oo ka falcelin kara reageniyeyaasha kale ama samayn kara isbeddello aan la rabin inta lagu jiro isku-darka.Iyagoo si door ah u ilaalinaya kooxo gaar ah oo hydroxyl ah oo isticmaalaya TMS-D-glucose lactone, farmashiyeyaashu waxay xakameyn karaan natiijooyinka falcelinta waxayna si wax ku ool ah u maareeyaan qaababka karbohaydraytyada.Ka dib markii falcelinta la rabay la dhammeeyo, kooxaha ilaalinta si fudud ayaa looga saari karaa, oo muujinaya badeecada la rabo.TMS-D-glucose lactone sidoo kale waxay helaysaa codsiyada sida dhexdhexaadka ah ee isku-dhafka ka-hortagga karbohaydraytyada kakan.Iyagoo si door ah wax uga beddelaya kooxaha hydroxyl ee TMS-D-glucose lactone, farmashiyeyaashu waxay soo bandhigi karaan kooxo badan oo shaqeynaya ama beddelaad kale oo ku jira molecule carbohydrate.Tani waxay u oggolaaneysaa abuurista xeryahooda carbohydrate-ku-saleysan ee kala duwan oo leh codsiyada suurtagalka ah ee daawooyinka, qurxinta, iyo sayniska alaabta. Intaa waxaa dheer, TMS-D-glucose lactone waxaa loo isticmaalaa isku-darka deeq-bixiyeyaasha glycosyl ee falcelinta glycosylation.Glycosylation waa tallaabo muhiim ah oo ku saabsan samaynta curaarta glycosidic, kuwaas oo lagama maarmaan u ah dhismaha karbohaydraytyada iyo glycoconjugates.TMS-D-glucose lactone waxaa loo bedeli karaa deeq-bixiyeyaasha glycosyl, kuwaas oo u dhaqma sida dhexdhexaadiyeyaasha falcelinta ee falcelinta glycosylation, taas oo awood u siinaysa ku-xidhka karbohaydraytyada molecules kale. Intaa waxaa dheer, TMS-D-glucose lactone waxaa loo shaqeeyaa soo saarista polymers-ku salaysan karbohaydrayt.Marka la hoosgeliyo TMS-D-glucose lactone falcelinta polymerization, farmashiyeyaashu waxay abuuri karaan silsilado polymer ama shabakado leh laf-dhabar carbohydrate.polymers-ka karbohaydraytyadani waxa ay yeelan karaan sifooyin gaar ah waxaana laga yaabaa inay ka helaan codsiyada meelaha sida hababka gudbinta daroogada, bioengineering, iyo biomaterials. Waxaa xusid mudan in TMS-D-glucose lactone waa in si taxadar leh loogu maareeyaa qoyaanka iyo dareenka hawada.Waxaa sida caadiga ah lagu kaydiyaa oo lagu maamulaa hoostooda nitrogen ama jawiga argon si looga hortago xaalufka kiimikada karbohaydrayt.Codsiyada aasaasiga ah waxaa ka mid ah ilaalinta kiimikada kooxda, isku-dhafka dhexdhexaadka ah, samaynta ku-deeqaha glycosyl, iyo soo-saarka polymers-ku-saleysan karbohaydrayt.Iyadoo la adeegsanayo TMS-D-glucose lactone hababkan, farmashiyeyaashu waxay ku gaari karaan xakameyn wanaagsan oo ku saabsan falcelinta karbohaydraytyada waxayna abuuraan noocyo kala duwan oo karbohaydraytyo ah oo leh codsiyo suurtagal ah oo dhinacyo kala duwan leh.