Alaabta

2-Pyrrolidinecarboxamide, 1- (2-chloroacetyl) -, (2S) - waa xarun leh codsiyo kala duwan oo ku saabsan kiimikada organic iyo cilmi-baarista dawooyinka.Xaruntan, oo sidoo kale loo yaqaan (2S) -2-Pyrrolidinecarboxamido-2-chloroacetic acid amide, waxay soo bandhigtaa sifooyin dhismeed oo ka dhigaya mid ku haboon falcelinta kiimikada qaarkood iyo daraasadaha noolaha. Acid amide waxaa loo isticmaali karaa sidii walxo bilow ah ama dhexdhexaad ah ee isku dhafka molecules kakan.Dabeecaddeeda chiral, oo leh magac-u-dhigid (2S), waxay tusinaysaa inay leedahay habayn saddex-geesood ah oo gaar ah oo atamka saamayn ku yeelan kara stereochemistry iyo sifooyinka asalkiisa.Hantidan ayaa ka dhigaysa mid qiimo leh oo ku jirta naqshadeynta iyo soo saarista dawooyinka cusub iyo xeryahooda dawooyinka.In warshadaha dawooyinka, (2S) -2-Pyrrolidinecarboxamido-2-chloroacetic acid amide ayaa lagu bartay awooddeeda sida xakameynta enzymes ama borotiinnada ku lug leh hababka bayoolojiga gaarka ah.Cilmi-baadhisyada qaar ayaa diiradda saaray codsigeeda sida xannibaadaha borotiinka qaarkood, kuwaas oo ah enzymes kuwaas oo door ka ciyaara hababka jireed ee kala duwan.Iyadoo la dooranayo oo la xakameynayo proteases-yadan, saameynaha daweynta ee ku habboon ayaa la gaari karaa. Intaa waxaa dheer, (2S) -2-Pyrrolidinecarboxamido-2-chloroacetic acid amide waxay u adeegi kartaa horudhac u ah isku-dhafka peptide analogs ama mimetics.Unugyadani waxay la jaanqaadi karaan qaab-dhismeedka iyo shaqada peptides-ka si dabiici ah u dhaca, si ay u saameeyaan bartilmaameedyo gaar ah ama hawlo bayooloji ah.Analoogyada noocan oo kale ah waxay yeelan karaan codsiyo suurtagal ah oo ku saabsan horumarinta daawooyinka loogu talagalay daaweynta cudurrada kala duwan, oo ay ku jiraan kansarka, cilladaha dheef-shiid kiimikaadka, iyo xaaladaha neerfaha. Waxaa muhiim ah in la ogaado in (2S) -2-Pyrrolidinecarboxamido-2-chloroacetic acid amide ayaa ugu horreyn loo isticmaalaa. cilmi baadhista shaybaadhka loomana ogola isticmaalka kiliinikada.Codsiyada daweynta ee suurtogalka ah ee xarunta ayaa weli la baarayaa, waxaana loo baahan yahay cilmi-baaris dheeraad ah si loo go'aamiyo badbaadada iyo waxtarkeeda bani-aadmiga. Gabagabadii, (2S) -2-Pyrrolidinecarboxamido-2-chloroacetic acid amide waa xarun leh codsiyo kala duwan oo ku saabsan isku-dhafka organic iyo cilmi baarista dawooyinka.Dabeecaddeeda chiral iyo kartida ay u leedahay joojinta enzymes gaar ah ama borotiinka ayaa ka dhigaya mid qiimo leh horumarinta daawooyinka cusub iyo xeeladaha daaweynta.Iyadoo isticmaalkeeda cilmi-baarista shaybaarka ay muujinayso ballanqaad, baaritaan dheeraad ah ayaa lagama maarmaan u ah si loo fahmo suurtagalnimada codsiyada bukaan-socodka.