Alaabta

Cerebral dopamine neurotrophic factor (CDNF) borotiinka ayaa lagu muujiyay inuu ilaaliyo dariiqa dopaminergic nigrostriatal marka la siiyo faleebo gudaha ah ee jiirka iyo moodooyinka jiirka ee cudurka Parkinson (PD).Daraasaddan, waxaan ku qiimeynay saameynta neuroprotective ee CDNF oo la keenay dib-u-soo-celinta adeno-la-xiriirta fayraska (AAV) serotype 2 vector ee jiirka 6-hydroxydopamine (6-OHDA) ee PD.AAV2 vectors codeed CDNF, glial cell line-derived neurotrophic factor (GDNF), ama borotiinka fluorescent cagaaran ayaa lagu duray marinka jiirka.Falanqaynta muujinta borotiinka waxay muujisay in vector-kayaga AAV2 uu si hufan u gaadhsiiyay hiddo-wadaha neurotrophic ee maskaxda oo uu kiciyay muujinta borotiinka oo waara.Laba toddobaad ka dib duritaanka AAV2 vector, 6-OHDA ayaa lagu duray jiirka jiirka, taasoo abuurtay hoos u dhac horumarsan oo ah nidaamka dopaminergic nigrostriatal.Daawaynta AAV2-CDNF waxay keentay hoos u dhac muuqda oo ku yimid wareegyada ipsilateral ee amphetamine-ku keeno iyada oo bixisa kaliya ilaalinta qayb ka mid ah unugyada tyrosine hydroxylase (TH) -immunoreactive unugyada rat substantia nigra pars compacta iyo fiilooyinka TH-reactive ee striatum.Natiijooyinka daraasaddan waxay bixiyaan caddayn dheeraad ah in CDNF loo tixgelin karo daaweynta suurtagalka ah ee cudurka Parkinson