2- (3,5-Dimethyl-4- (2- (pyrrolidin-1-yl) ethoxy) phenyl) -5,7-dimethoxyquinazolin-4 (3H) -hal Cas: 1044871-04-6
Lambarka buugaagta | XD90961 |
Magaca Alaabta | 2- (3,5-Dimethyl-4- (2- (pyrrolidin-1-yl) ethoxy) phenyl) -5,7-dimethoxyquinazolin-4 (3H) -hal |
CAS | 1044871-04-6 |
Qaanuunka molecular | C24H29N3O4 |
Miisaanka Molecular | 423.5 |
Faahfaahinta Kaydinta | |
Xeerka Tarifka La Iswaafajiyay |
Tilmaamaha Alaabta
Muuqashada | |
Qiimayn | |
Bbarta saliidda | 612.6± 65.0 °C (La saadaaliyay) |
Cufnaanta | 1.25±0.1 g/cm3 (La saadaaliyay) |
Isku-dhafka aysiidhka | (pKa)9.54±0.20 (La saadaaliyay) |
RVX-297 waa mid aad u xoog badan, oo afka ka shaqeeya inhibitor BET oo doorta BD2.IC50s ee RVX-297 ee BRD2(BD2), BRD3(BD2), iyo BRD4(BD2) waxay ahaayeen 0.08, 0.05, iyo 0.02 μM, siday u kala horreeyaan.RVX-297 waxay joojisaa muujinta hiddo-wadaha caabuqa unugyada difaaca ee kala duwan.Waxtarka RVX-297 ee qaababka hore ee caabuqa degdega ah iyo difaaca jirka.
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