Alaabta

2- (3-Formyl-4-hydroxy-phenyl) -4-methyl-thiazole-5-carboxylic acid ethyl ester waa isku-dhismeed kiimiko ah oo haya ballan-qaadka goobta daawooyinka sababtoo ah qaab-dhismeedkeeda gaarka ah iyo hawlaha bayoolojiga ee suurtogalka ah.Xaruntan waxaa loo isticmaali karaa noocyo kala duwan oo kimistari daawooyin ah iyo hababka helitaanka daroogada. Mid ka mid ah isticmaalka suurtagalka ah ee 2- (3-Formyl-4-hydroxy-phenyl) -4-methyl-thiazole-5-carboxylic acid ethyl ester waa qalab bilow ah. loogu talagalay isku dhafka daawooyinka cusub.Qaab dhismeedkeedu waxa uu ka kooban yahay kooxo shaqaynaya oo samayn kara wax ka beddel iyo isbeddel, taas oo u oggolaanaysa farmashiyeyaasha dawooyinka inay soo bandhigaan beddelaadyo kala duwan oo ay abuuraan unugyo kala duwan oo leh astaamo dawooyin la xoojiyay.Iyadoo si nidaamsan wax looga beddelayo xaruntan, cilmi-baarayaashu waxay soo saari karaan maktabad asal ah oo loogu talagalay daraasadaha xiriirka-shaqo-dhismeedka (SAR), qiimeynta saameynta isbeddellada kala duwan ee awoodda daroogada, xulashada, iyo guryaha farmashiyaha. Intaa waxaa dheer, xaruntan ayaa laga yaabaa inay muujiso waxqabadyada nafleyda ee lafteeda lafteeda. , kaas oo lagu sahamin karo codsiyada daweynta ee suurtogalka ah.Joogitaanka giraanta thiazol iyo koox formyl ah oo ay weheliso qayb phenolic ah ayaa soo jeedinaysa inay lahaan karto sifooyinka antioxidant iyo anti-bararka.Guryahaas waxaa badanaa lagu raadiyaa horumarinta daroogada, maadaama ay gacan ka geysan karaan ka hortagga ama daaweynta cudurrada kala duwan ee la xiriira cadaadiska oksaydhka iyo hababka bararka, sida cudurrada wadnaha iyo xididdada neerfaha. 2- (3-Formyl-4-hydroxy- phenyl) -4-methyl-thiazole-5-carboxylic acid ethyl ester waxa kale oo loo isticmaali karaa in lagu barto isdhexgalka enzyme-substrate-ka.Enzymes-ku waxay door muhiim ah ka ciyaaraan hababka noole ee kala duwan waxayna inta badan ku lug leeyihiin cudurada.Marka la naqshadeeyo isku-dhafka isku-dhafka ah ee dhismahan iyo baaritaanka isdhexgalka ee enzymes gaar ah, cilmi-baarayaashu waxay heli karaan fikrado ku saabsan dhaqdhaqaaqa enzymatic waxayna suurtogal u tahay inay aqoonsadaan bartilmaameedyada cusub ee daroogada, gaar ahaan xaaladaha la xidhiidha cillad-darrada enzymatic. Intaa waxaa dheer, xaruntan waxaa loo isticmaali karaa qaab-dhismeedka qaab-dhismeedka daroogada qaabaynta hababka qaabaynta daroogada. .Qaab dhismeedkeeda gaarka ah ayaa ka dhigaya mid ku habboon daraasadaha docking iyo qaabaynta molecular, halkaas oo cilmi-baarayaashu ay saadaalin karaan habka isku-xidhka xarunta ee borotiinnada bartilmaameedka ah oo ay wanaajiyaan is-dhexgalka si kor loogu qaado waxtarka. Gabagabadii, 2- (3-Formyl-4-hydroxy-phenyl) -4-methyl-thiazole-5-carboxylic acid ethyl ester waxay muujinaysaa faa'iidada suurtagalka ah ee kimisteriga dawada iyo helitaanka daroogada.Waxay u adeegi kartaa meel qiimo leh oo laga bilaabo isku-dhafka xeryahooda cusub ee leh sifooyinka dawooyinka ee la xoojiyay.Intaa waxaa dheer, hawlaheeda bayooloji ee gudaha ee suurtagalka ah iyo isdhexgalka enzymes-ka ayaa ka dhigaya musharax xiiso leh ee sahaminta dheeraadka ah ee codsiyada daweynta.Baaritaanka iyo baaritaanka joogtada ah ayaa daaha ka qaadi doona awoodda buuxda ee xaruntan horumarinta daawooyinka cusub iyo fahamka hababka noolaha.