Alaabta

(1R,2S,5S)—6,6-DiMethyl-3-aza-bicylo[3.1.0]hexane-2-carboxylic acid Methyl ester hydrochloride waa isku dhaf kiimiko ah oo leh codsiyo kala duwan oo ku saabsan cilmi baarista dawooyinka iyo horumarinta daroogada. Mid ka mid ah Isticmaalka muhiimka ah ee xaruntan waa sida dhisme chiral ah oo ka mid ah isku-darka dhexdhexaadiyeyaasha dawooyinka iyo maaddooyinka dawooyinka firfircoon (APIs).Qaab dhismeedkeeda gaarka ah ee baaskiilka iyo chirality ayaa ka dhigaya mid qiimo leh soo saarista isku-dhisyada saafiga ah ee enantiomerically.Marka lagu daro xaruntan isku-dhafka ah, farmashiyeyaashu waxay xakameyn karaan stereochemistry oo ay ku abuuraan sifooyin farmaajo gaar ah oo ku jira molecules ka soo baxa.Tani waxay si gaar ah muhiim ugu tahay horumarinta daroogada, halkaasoo dhaqdhaqaaqa nafleyda ee la rabo inta badan ay ku xiran tahay habka booska ee molecule. Intaa waxaa dheer, (1R,2S,5S) -6,6-DiMethyl-3-aza-bicylo[3.1.0] hexane -2-carboxylic acid Methyl ester hydrochloride waxaa loo isticmaalaa horudhac u ah isku dhafka daawooyinka quinclidine.Kala soocida Quinuclidine waxay muujisay waxqabadyo bayooloji oo kala duwan, oo ay ku jiraan antipsychotic, anticonvulsant, iyo sifooyinka xanuunka.Iyaga oo soo bandhigaya kooxo gaar ah oo shaqeynaya xarunta, farmashiyeyaashu waxay wax ka beddeli karaan farmashiyaha iyo guryaha farmashiyaha, iyagoo kor u qaadaya awoodeeda daweynta. Intaa waxaa dheer, xaruntani waxay u aragtaa isticmaalka falcelinta ama kicinta isbeddellada organic.Sababtoo ah joogitaanka amine sare iyo dabeecadda adag ee adag ee kooxaha methyl, waxay ka qayb qaadan kartaa falcelin kiimikaad oo kala duwan, sida amidation, alkylation, iyo falcelinta cycloaddition.Dhaqdhaqaaqeeda iyo kartida ay u sameyso dhexdhexaadin adag ayaa ka dhigaysa qalab wax ku ool ah oo ku jira isku-dhafka dabiiciga ah, taas oo u oggolaanaysa abuurista isku-dhafka qaab-dhismeedka kala duwan. Soo koobid, (1R,2S,5S) -6,6-DiMethyl-3-aza-bicylo .0]hexane-2-carboxylic acid Methyl ester hydrochloride waa xarun qiimo leh oo ku jirta horumarinta daroogada iyo isku dhafka dabiiciga ah.Chirality-keeda iyo qaab-dhismeedkeeda gaarka ah waxay awood u siinaysaa soo saarista xeryahooda enantiomerically saafi ah iyo isku-darka dawooyinka quinclidine-ku-salaysan oo leh sifooyin dawooyin gaar ah.Falcelinteedu waxay sidoo kale ka dhigtaa falcelin faa'iido leh iyo kicinta isbeddelada kiimikada ee kala duwan.Guud ahaan, xaruntani waxay door muhiim ah ka ciyaartaa horumarinta cilmi-baarista dawooyinka iyo horumarinta wakiilada cusub ee daaweynta.