Alaabta

1- (4-Methoxyphenyl) -7-oxo-6-[4- (2-oxopiperidin-1-yl) phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c] pyridine -3-carboxylic acid ethyl ester waa iskudhis kiimiko ah oo isku dhafan taas oo muujisay karti meelo kala duwan oo kimistari daawo ah iyo helitaanka daroogada.Halkan waxaa ah sharaxaad ku saabsan isticmaalkeeda oo ku saabsan ereyada 300. Xaruntan, oo badanaa loo yaqaan 'ethyl ester derivative' ee 1- (4-Methoxyphenyl) -7-oxo-6- [4- (2-oxopiperidin-1-yl) phenyl] -4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid, waxay ka tirsan tahay fasalka pyrazolo [3,4-c] pyridine derivatives.Soosaarayaashan ayaa soo jiitay dareenka helitaanka daroogada sababtoo ah awoodooda meelaha kala duwan ee daaweyntaPyrazolo[3,4-c] derivatives pyridine waxay soo bandhigeen waxqabadyo ka hortag ah oo ka dhan ah dhowr nooc oo unugyada kansarka ah.Awoodda ay u leeyihiin inay joojiyaan dariiqyo gaar ah oo ku lug leh koritaanka burooyinka iyo badbaadada ayaa ka dhigaysa musharaxiin karti u leh horumarinta daawooyinka ka hortagga kansarka.Daraasado dheeraad ah ayaa loo baahan yahay si loo sahamiyo habka ficilka oo loo qiimeeyo waxtarka xarunta ee goobaha hore ee daaweynta iyo daaweynta. Intaa waxaa dheer, xaruntani waxay muujisay ballanqaad sida wakiilka bakteeriyada ee suurtogalka ah.Waxay soo bandhigtay waxqabad ka dhan ah noocyada kala duwan ee bakteeriyada, oo ay ku jiraan bakteeriyada Gram-positive iyo Gram-negative labadaba.Awoodda lagu beegsanayo noocyo badan ayaa soo jeedinaysa awoodda ay u leedahay la-dagaallanka bakteeriyada daawada u adkeysata, taas oo noqotay walaac caafimaad oo caalami ah.Cilmi-baaris dheeraad ah ayaa loo dammaanad qaadayaa in la baaro qaabka ficilkeeda oo loo qiimeeyo waxtarkeeda la dagaallanka caabuqyada bakteeriyada. Intaa waxaa dheer, pyrazolo [3,4-c] pyridine derivatives, oo ay ku jiraan xaruntan, waxay muujiyeen suurtagalnimada daaweynta cudurrada bararka iyo difaaca jirka.Caabuqa ayaa door muhiim ah ka ciyaara xaalado kala duwan sida rheumatoid arthritis-ka iyo psoriasis.Soosaarayaashan ayaa soo bandhigay sifooyinka anti-bararka iyaga oo wax ka beddelaya dariiqyo gaar ah oo ku lug leh falcelinta bararka.Tani waxay soo jeedinaysaa awooddooda sida wakiilada daweynta ee maaraynta caabuqa dabadheeraad ah iyo cudurrada la xidhiidha. Intaa waxaa dheer, xaruntani waxay muujisay firfircoonida habka dhexe ee neerfayaasha (CNS).Waxaa lagu baaray suurtagalnimada jirrooyinka neerfaha sida cudurka Alzheimers iyo cudurka Parkinson.Xarunta ayaa laga yaabaa inay wax ka beddesho reseptors gaar ah iyo enzymes ku lug leh horumarka cudurka, oo laga yaabo inay bixiyaan saamaynta neuroprotective.Si kastaba ha ahaatee, cilmi-baaris dheeraad ah ayaa loo baahan yahay si loo fahmo habka ay u shaqeyso oo loo qiimeeyo waxtarkeeda daaweynta cudurradan kakan. yl) phenyl] -4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c] pyridine-3-carboxylic acid ethyl ester waxay ballan ku haysaa meelo badan oo daweyn ah, oo ay ku jiraan anti-kansarka, bakteeriyada, anti-bararka. , iyo xanuunada CNS.Awooddeedu waxay ku jirtaa awoodda ay u leedahay inay beegsato dariiqyo gaar ah iyo soo-dhoweeyayaasha ku lug leh xaaladahan.Si kastaba ha ahaatee, cilmi baaris dheeraad ah iyo baaritaan ayaa lagama maarmaan u ah in si buuxda loo sahamiyo awooddeeda, kor loogu qaado hantideeda, loona qiimeeyo ammaankeeda iyo waxtarkeeda goobaha caafimaadka.