Alaabta

1- (4-Fluorophenyl) piperazine dihydrochloride, oo sidoo kale loo yaqaan 4-FPP, waa xarun kiimiko oo ka hela codsiyada kala duwan ee farmashiyaha iyo cilmi-baarista.Qaab dhismeedka molecular ee gaarka ah oo ay ku jiraan atom fluorine iyo giraanta piperazine waxay ka dhigaysaa mid qiimo leh ujeedooyin kala duwan, laga bilaabo horumarinta daroogada ilaa baaritaanka sayniska. dhowr daawo oo daweyn ah.Iyada oo ay ugu wacan tahay awoodda ay u leedahay in ay marto wax ka beddelka kiimikaad, waxay awood u siinaysaa abuurista musharraxiinta daroogada cusub ee leh firfircoonida dawooyinka suurtagalka ah.Joogitaanka qaybta piperazine ee qaab-dhismeedkeeda ayaa si gaar ah faa'iido u leh horumarinta daawooyinka lagu beegsanayo habka dhexe ee neerfayaasha, sida antipsychotics, antidepressants, iyo wakiilada walaaca. Intaa waxaa dheer, 1- (4-Fluorophenyl) Piperazine dihydrochloride ayaa si joogta ah loogu shaqeeyaa cilmi baaris cilmiyeed si loo baaro hababka noole kala duwan.Sida molecule qalab badan, waxaa loo isticmaalaa in lagu barto isku-xirnaanta soo-dhoweynta, isdhexgalka neurochemical, iyo saameynta daawooyinka hababka gaarka ah ee jirka.Cilmi-baarayaashu waxay ka faa'iidaystaan ​​xaruntan si ay u furfuraan hababka ficilka daawooyinka kala duwan, sare u qaadida noocyada hoose ee reseptor, iyo sahaminta dariiqyada gudbinta calaamadaha.Marka la helo faham qoto dheer oo ku saabsan hababkan, saynisyahannadu waxay horumarin karaan aqoonta ku hareeraysan cudurro badan oo neerfaha iyo maskaxda ah, oo u gogol xaaraya horumarinta xeeladaha daaweynta cusub isku dhafka radioligands for positron emission tomography (PET).Radioligands oo ku salaysan xaruntan, oo lagu calaamadiyay isotopes shucaac ah, ayaa u oggolaanaya muuqaal aan fiicneyn iyo qiyaasida hababka biochemical ee gaarka ah ee jirka bini'aadamka.Farsamooyinka sawir-qaadista noocan oo kale ah waxay bixiyaan fikrado qiimo leh oo ku saabsan qaybinta soo-dhoweynta, deganaanshaha, iyo cufnaanta, ka caawinta sahaminta xaaladaha kala duwan ee neerfaha iyo caawinta horumarinta hababka daaweynta ee la beegsanayo. Waa lagama maarmaan in la xakameeyo 1- (4-Fluorophenyl) dihydrochloride piperazine si taxadar leh, maadaama loo arko inay tahay walax khatar ah.Tallaabooyin nabdoon oo ku habboon iyo qalabka ilaalinta shakhsi ahaaneed waa in la adeegsadaa si loo yareeyo khatarta shilalka soo-gaadhista ama si xun u maaraynta.Guud ahaan, 1- (4-Fluorophenyl) Piperazine dihydrochloride waa isku-dhismeed isku dhafan oo laga isticmaalo qaybaha dawooyinka iyo cilmi-baarista.Codsiyadeedu waxay ka kooban yihiin isku-darka daroogada, daraasadda hababka noolaha, iyo horumarinta radioligands ee sawirka PET.Aqoonta dhismaha xarunta iyo sida taxadarka leh ee loo maareeyo ayaa muhiim u ah xaqiijinta amniga iyo fududeynta wax qabadkeeda qiimaha leh ee horumarinta sayniska iyo daawada.