Alaabta

1- (3-Hydroxymethylpyridin-2-yl) -4-methyl-2-phenylpiperazine waa xarun kiimiko ah oo leh codsiyo kala duwan oo kala duwan oo suurtagal ah oo ku saabsan kiimikada daawada iyo horumarinta daroogada. , gaar ahaan helitaanka daroogada.Joogitaanka kooxda hydroxymethylpyridinyl waxay soo jeedinaysaa isdhexgalka suurtagalka ah ee bartilmaameedyada bayoolojiga gaarka ah, sida enzymes ama reseptors.Farmashiyeyaasha dawooyinka ayaa wanaajin kara qaab dhismeedka xaruntan si ay u wanaajiyaan isku xidhnaanta iyo xulashada bartilmaameedyada noolaha ee la doonayo.Iyada oo wax laga beddelayo qaybaha phenyl iyo piperazine, cilmi-baarayaashu waxay si fiican u hagaajin karaan guryaha physicochemical ee xarunta iyo farmashiyaha, taas oo keeni karta hagaajinta waxtarka daawada iyo hoos u dhigista waxyeellooyinka aan la rabin. Codsiga kale ee suurtagalka ah ee 1- (3-Hydroxymethylpyridin-2-yl) -methyl-2-phenylpiperazine waxay ku taal berrinka neuropharmacology.Qaab dhismeedka xaruntani waxa uu soo jeedinayaa isdhexgalka suurtagalka ah ee lala yeesho reseptors ee habdhiska dhexe ee neerfayaasha, taas oo suurta gal ah in ay keento saamaynta daweynta ee xanuunada neerfaha.Tusaale ahaan, waxaa loo sahamin karaa musharax ahaan beddelka neurotransmission xaaladaha sida walaaca, niyad-jabka, ama schizophrenia.Cilmi-baadhayaashu waxay baadhi karaan habka wax-qabadka xarunta waxayna sameeyaan daraasado caafimaad iyo kuwo caafimaad si ay u qiimeeyaan awoodeeda daawayntaKooxaheeda hydrophobic phenyl iyo methyl waxay soo jeedinayaan suurtagalnimada in laga gudbo xuubka dufanka, taas oo awood u siineysa inay beegsato enzymes-ka unugyada ama waddooyinka.Hantidani waxay faa'iido u leedahay horumarinta daawooyinka u baahan inay galaan unugyada oo ay ku sameeyaan saameyntooda bartilmaameedyo gaar ah oo gudaha ah.Iyada oo wax laga beddelayo qaab-dhismeedka xarunta, farmashiyeyaasha dawooyinka ayaa kor u qaadi kara bioavailability-ga, hagaajinta xasilloonida, iyo horumarinta xeeladaha gudbinta daroogada waxtarka leh. Waxaa muhiim ah in la ogaado in isticmaalka 1- (3-Hydroxymethylpyridin-2-yl) -4-methyl-2 -phenylpiperazine ee codsiyadan suurtagalka ah waxay u baahan tahay qiimeyn caafimaad oo sahal ah iyo mid caafimaad si loo hubiyo badbaadada, waxtarka, iyo qiyaasta habboon.Daraasado fara badan oo dawooyinka iyo sunta sunta ah ayaa lagama maarmaan u ah in la fahmo saameynta ay ku leedahay nidaamyada bayooloji ee kala duwan iyo in la go'aamiyo wax kasta oo saameyn xun ku yeelan kara.. Codsiyada suurtagalka ah ee kimisteriga daawada iyo horumarinta daroogada.Waxay ballan qaadaysaa naqshadeynta dawooyinka cusub, gaar ahaan meelaha neuropharmacology iyo gaarsiinta daroogada.Cilmi-baaris dheeraad ah ayaa loo baahan yahay si loo sahamiyo is-dhexgalkeeda gaarka ah, habka ficilka, iyo awoodda daaweynta, taas oo u gogol xaareysa horumarka suurtagalka ah ee daaweynta cudurrada iyo cudurrada kala duwan.