Alaabta

(αS,3S)-α-[(tert-Butyloxycarbonyl) amino]-2-oxo-3-pyrrolidinepropanoic acid methyl ester, oo sidoo kale loo yaqaan Boc-Amino acid methyl ester, waa xarun muhiim ah oo ku taal berrinka isku-dhafka organic iyo peptide. chemistry.Boc-Amino acid methyl ester waxay u adeegtaa qaab la ilaaliyo oo amino acids ah, halkaas oo kooxda Boc (tert-butyloxycarbonyl) loo isticmaalo si loo ilaaliyo kooxda amino inta lagu jiro falcelinta.Xaruntan waxaa ugu horrayn looga faa'iidaystaa isku-dhafka peptide si loogu soo bandhigo asiidhyo amino gaar ah silsiladaha peptide.Waxay ku lug leeyihiin habab kala duwan sida calaamadaynta, xakamaynta enzyme, iyo taageerada qaabdhismeedka.Isku-dubarid Peptide waxay ku lug leedahay isu-ururinta asiidhyada amino-yada si ay u abuurto taxane gaar ah oo u ekaanaya peptides-ka dabiiciga ah ama abuurista qaabab cusub oo leh sifooyin la doonayo. Mid ka mid ah hababka ugu ballaaran ee loo isticmaalo in lagu dhiso peptides.Gudaha SPPS, silsiladda peptide-ka waxaa loo habeeyey si tartiib tartiib ah iyadoo la adeegsanayo taageero adag, sida caadiga ah iyadoo la adeegsanayo soosaarayaasha amino acid oo leh koox ilaalin ku meel gaar ah.Boc-Amino acid methyl ester waa qalab bilow ah oo ku habboon SPPS sababtoo ah xasilloonideeda, milmaheeda, iyo la jaanqaadka reagents-ku-samaynta kale ee peptide. Inta lagu jiro synthesis peptide, Boc-Amino acid methyl ester waxaa lagu daraa silsiladda peptide ee sii kordheysa iyada oo loo marayo samaynta curaarta amide.Kooxda ilaalinta Boc waxay ka hortagtaa falcelinta dhinaca aan loo baahnayn waxayna hubisaa isku xidhka xulashada ee amino acid silsiladda peptide.Marka la gaaro isku xigxiga la rabay, kooxda Boc ayaa laga saarayaa xaalado khafiif ah, oo muujinaya kooxda amino-ka bilaashka ah ee isbeddelka dheeraadka ah ama sifooyinka peptide. Marka lagu daro isku-darka peptide, Boc-Amino acid methyl ester ayaa sidoo kale loo isticmaali karaa diyaarinta dawooyinka kala duwan. dhexdhexaadinta, agrochemicals, iyo xeryahooda kale ee organic.Maareynteeda sahlan, xasilloonida, iyo waafaqsanaanta xaaladaha falcelinta caadiga ah waxay ka dhigtaa dhismo dhismeed oo kala duwan oo loogu talagalay isku-darka organic. Guud ahaan, Boc-Amino acid methyl ester waa qalab qiimo leh oo ku jira isku-dhafka peptide iyo kiimikada organic.Doorkeeda sida qaabka la ilaaliyo ee acids amino waxay u oggolaaneysaa isku-dhafka hufan ee silsiladaha peptide iyo abuurista qaabab kala duwan oo peptide ah oo loogu talagalay cilmi-baarista, helitaanka daroogada, iyo codsiyada daaweynta.